Intramyometrial Injection of Vasopressin: A Novel Method for Hemostasis at Laparoscopic Management of Cornual Ectopic.

STUDY OBJECTIVE: Although all ectopic pregnancies are associated with risk of hemorrhage, cornual pregnancies are feared for catastrophic hemorrhage and uncontrollable bleeding. The maternal mortality rate can be as high as 2.5%, which is 7 times higher than the mortality rate for ectopic pregnancies in general. Different techniques have been used to control hemostasis, including purse string suture, square suture, endo-loop, electrocoagulation, and devascularization. Injection of vasopressin into the uterus is a simple method that greatly reduces the blood loss at cornuostomy. DESIGN: A step by step demonstration of the surgical procedure (Canadian Task Force classification III). SETTING: Hospital. PATIENT, INTERVENTIONS, MEASUREMENTS AND MAIN RESULTS: A 32-year-old woman, G7P3L3A3 (Gravida 7, Para 3, Living 3, Abortion 3), with 4 months of amenorrhea, was diagnosed with a cornual ectopic pregnancy. She was treated with 200 mg mifepristone and 800 µg misoprostol. She had undergone dilatation and curettage twice and was referred for persisting cornual ectopic pregnancy. At laparoscopy, 20 U injection vasopressin in 100 mL .9% normal saline was injected into the myometrium of the uterus. Incision was made over the ectopic pregnancy with ultrasonic energy and the ectopic pregnancy enucleated using suction apparatus and ultrasonic energy. Hemostasis was ensured and the bed sutured with barbed suture. Surgery duration was 1 hour, and blood loss was 200 mL. Institutional review board and ethics committee approval was obtained. CONCLUSION: Injection of vasopressin into the uterus significantly reduces blood loss, operative time, and patient morbidity and mortality at laparoscopic cornuostomy.

Laparoscopic Hysterectomies: Our 10 Years Experience in a Single Laparoscopic Center.

STUDY OBJECTIVE: To evaluate the association between outcomes of laparoscopic hysterectomy with respect to clinical factors, intraoperative variants, and post-operative complications. DESIGN: The study conducted was retrospective (Canadian Task Force Classification II-1). SETTING: The set used in this study was a gynecological laparoscopic centre. PATIENTS: The present study included 858 women who underwent laparoscopic hysterectomies with or without bilateral/unilateral salpingo-oophorectomy, from December 2004 to May 2014. INTERVENTIONS: Eight hundred and sixteen patients underwent total laparoscopic hysterectomy, 14 patients underwent subtotal laparoscopic hysterectomy, 20 patients underwent laparoscopic-assisted vaginal hysterectomy, and 8 patients underwent laparoscopic radical hysterectomy with bilateral pelvic lymph node dissection. MEASUREMENTS AND MAIN RESULTS: All surgeries were performed by the same surgeon, using the same surgical technique. The medical records were reviewed, and data were collected with respect to age, indications, type of surgery performed, intraoperative variants, and post-operative complications. Patient average age was 44.9 ± 6.2 years. Most common indication for benign TLH was leiomyoma of 54.4 %. Indications for laparoscopic radical hysterectomy were early stage endometrial cancer (n = 5) and early stage cervical cancer (n = 3). The maximum uterine size operated on was from 20-26 weeks, 4.9 % (n = 42). 9.7 % had previous abdominopelvic surgery. Fifty three % underwent unilateral/bilateral salpingo-oophorectomy. Conversion rate was 0.93 % (n = 8). The minimum and maximum operating time during the total study period was 20 min-2 h. The major complication rates were 0.9 % (n = 8). The hospital stay was not more than 2 days. CONCLUSION: In our experience of 858 laparoscopic hysterectomies, 850 were done for benign indications, and 8 done for malignancies. TLH can be performed more safely and under vision, with less blood loss, early post-operative recovery, less post-operative infection, and less complication rate.