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1.
Exp Oncol ; 43(2): 189-192, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34190509

RESUMO

For more than 35 years after Chornobyl catastrophe, about 5 million people in Ukraine, Republic of Belarus and Russian Federation inhabit the territories that are residually contaminated with long-lived radionuclides such as 137Cs, 90Sr. The previous studies of the Reference Laboratory operating at RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology allowed specifying the effects of the protracted low dose irradiation on the state of the hematopoietic and lymphoid tissues resulting in the increased proportion of the B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma and acute myeloid leukemia among the patients referred from the contaminated areas of Ukraine. Since the beginning of 2020, these effects of radiation were superimposed by the factors associated with COVID-19 pandemic. SARS-CoV-2 infection is associated with the significant impact on hematopoiesis and immune system. Particular attention should be given to the role of such combined burden in the development of the immunodeficiency-associated lymphoid neoplasms. The extensive studies of the combined effects of low dose irradiation and COVID-19 within the large affected populations could be made a priority in future endeavors of epidemiologists and oncohematologists.


Assuntos
COVID-19/epidemiologia , Neoplasias Hematológicas/epidemiologia , Radiação Ionizante , SARS-CoV-2/patogenicidade , COVID-19/complicações , COVID-19/virologia , Acidente Nuclear de Chernobyl , Neoplasias Hematológicas/complicações , Neoplasias Hematológicas/virologia , Humanos , Doses de Radiação
2.
Exp Oncol ; 43(1): 87-91, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33785720

RESUMO

The 2017 revision of WHO Classification of tumors of hematopoietic and lymphoid tissues contains separate chapters on the immunodeficiency-associated lymphoproliferative disorders. In this mini-review, the brief description of pathological, immunophenotypical and clinical features of lymphoid neoplasms associated with primary immune disorders, HIV infection, those arising in post-transplant setting and other lymphoproliferative disorders (excluding those induced by radiation) is given. The heterogeneous spectrum of these lymphoid malignancies is specified by the nature of those factors that are capable to induce immune suppression or chronic antigenic stimulation of immune system. Taking into account the full swing of SARS-CoV-2 pandemic and our ignorance of the ability of this virus to induce the sustained stimulation of immune system, we could not exclude the high risk of autoimmune diseases and lymphoid neoplasms in the long-term post-pandemic period. In this context, the role of angiotensin-converting enzyme 2  as well as some recently reported cell receptors for SARS-CoV-2 cell entry should be considered as far as some of them (CD147, CD26) could be tumor-associated antigens.


Assuntos
COVID-19/epidemiologia , Linfoma/epidemiologia , Transtornos Linfoproliferativos/epidemiologia , Enzima de Conversão de Angiotensina 2/fisiologia , Antígenos/fisiologia , COVID-19/complicações , Infecções por HIV , Humanos , Síndromes de Imunodeficiência/complicações , Síndromes de Imunodeficiência/epidemiologia , Imunofenotipagem , Linfoma/complicações , Transtornos Linfoproliferativos/complicações , Transplante de Órgãos/efeitos adversos , Pandemias , Transplantados
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