[The use of the results of a statistical analysis for the goal-directed correction of epidemic-control measures with respect to measles]. / Ispol'zovanie rezul'tatov statisticheskogo analiza dlia tselenapravlennoi korrektsii protivoépidemicheskikh meropriiatii v otnoshenii kori.

Measles morbidity and the state of the immune stratum among children during pre-epidemic, epidemic and post epidemic periods, taken separately, has been analyzed by a specially developed method of statistical analysis. With the immune stratum remaining the same, differences in morbidity rates in different years of the cycle have been revealed. The study has demonstrated that in the presence of a high level of the immune stratum measles morbidity retains its cyclic character, which may be attributed to the action of other factors on this process. Morbidity rate has been found to be influenced by such factor as the frequency of contacts with the source of infection, and in this connection the risk of contacting measles by nonimmune children varies in different age groups of children. Regressive equations have been constructed on the basis of the above approach, thus permitting the prognostication of measles morbidity for the coming year in individual groups of children, which is of importance for the scientifically substantiated and oriented correction of antiepidemic measures.

[The use of the cluster selection method for assessing the status of immunity to controlled infections (measles, diphtheria and tetanus)]. / Ispol'zovanie metoda klasternoi vyborki dlia otsenki sostoianiia immuniteta k upravliaemym infektsiiam (kori, difterii, stolbniaku).

The use of the method of cluster selection in mass serological examination makes it possible to obtain statistically significant results with very low expenditures. The coincidence of the results on the number of seronegative children, obtained by the method of cluster selection, with the results of mass serological examination of all children aged 6-7 years in the district (children found to be seronegative to measles constituted 5.5% and 5.0% respectively) is indicative of the statistical significance of the method used in this investigation. The results obtained by the method of cluster selection indicate that the level of protection among the children of the district was high both with respect to measles (94.5 +/- 1.8%) and tetanus (96.5 +/- 1.7%); with respect to diphtheria, the immune stratum was found to be less (91.1 +/- 2.3%). These data may be helpful in working out scientifically substantiated administrative decisions contributing to an increase in the effectiveness of planned mass immunization.

[The use of computers and mathematical methods for optimizing epidemic control measures with respect to measles infection]. / Ispol'zovanie EVM i matematicheskikh metodov dlia optimizatsii protivoépidemicheskikh meropriiatii v otnoshenii korevoi infektsii.

The potentialities of computers for the study of the effectiveness of immunization have been demonstrated and the mathematical model for the prediction of the proportion of children, seronegative to measles, derived on the basis of the data on the average measles morbidity in different groups for a given period. A multifactor analysis of a large scope of data obtained in seroepidemiological survey and a retrospective analysis of measles morbidity on the basis of data collected in two districts of Moscow have been carried out with the use of computers and mathematical methods.

[The validation of the expediency of a review of the times for revaccinating children against measles]. / Obosnovanie tselesoobraznosti peresmotra srokov revaktsinatsii detei protiv kori.

Basing on the results of seroepidemiological study, carried out in two districts of Moscow by different methods, cluster selection method including, the authors have developed the following recommendations aimed at improving the strategy of revaccination against measles: (1) selective revaccination of only seronegative children or those with poor antimeasles immunity should be carried out, thus making it possible to reduce the number of susceptible children and diminish the risk of postimmunization reactions and complications; (2) when determining the groups of children to be revaccinated and the age suitable for revaccination, one should bear in mind the specific local features of the epidemic process in measles and the morbidity values, as well as the data on antimeasles immunity in children of different age groups; (3) serologic monitoring of the quality and immunologic effectiveness of different batches of live measles vaccine permits timely removal of nonstandard batches from practical use, thus improving the efficacy of vaccinal prophylaxis of measles.

[A comparative evaluation of the immunological efficacy of ADPT vaccine and ADT-M anatoxin in the immunization of children against diphtheria and tetanus]. / Sravnitel'na otsenka immunologicheskoi éffektivnosati AKDS-vaktsiny i ADS-M-anatoksina pri immunizatsii detei protiv difterii i stolbniaka.

Comparative study of the immunological effectiveness of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine and adsorbed diphtheria-tetanus toxoid with reduced antigen content (adsorbed DT toxoid R) in the immunization of children, carried out in accordance with the vaccination schedule, was made. Immune response to the injection of adsorbed DPT vaccine was higher than after immunization with adsorbed DT toxoid R, as evidenced by antibody titers. It was probably due to differences in the number of injections constituting the course of immunization: it consisted of 3 injections and 1 booster injection for adsorbed DPT vaccine and 2 injections and 1 booster injection for adsorbed DT toxoid R. Immunization with adsorbed DPT vaccine produced immunity which was retained for a longer period. These results are indicative of the expediency of the primary immunization of children with adsorbed DT toxoid R introduced in three injections in order to ensure more stable and prolonged postvaccinal (mainly antidiphtheria) immunity.