RESUMO
BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic progressively scarring disease of the oral cavity. Lycopene is a powerful antioxidant obtained from tomatoes and has the highest singlet oxygen quenching capacity and a high capacity of quenching other free radicals in vitro among dietary carotenoids. Hyaluronidase is a substance prepared from the testes and semen of mammals that modifies the permeability of connective tissue through the hydrolysis of hyaluronic acid. OBJECTIVE: To evaluate the efficacy of lycopene and lycopene-hyaluronidase combination, and to compare the efficacy of lycopene and lycopene-hyaluronidase combination in the treatment of OSMF. STUDY DESIGN: The study consisted of 45 patients with OSMF divided into three equal groups. Patients in Group A were given Lycored 16 mg daily in two equally divided doses for 3 months. Patients in Group B were given LycoRed along with hyaluronidase intralesional injection of 1500 IU twice weekly for 3 months. Patients in Group C were given placebo capsules. Patients were evaluated after 3 months. The following parameters were recorded: mouth opening, visual inspection, palpatory findings, and burning sensation. RESULTS: There was statistically significant change in mouth opening and burning sensation for lycopene and lycopene-hyaluronidase combination than in the placebo group in the treatment of OSMF, but the lycopene-hyaluronidase combination did not show any statistically significant change when compared with lycopene alone. CONCLUSION: Lycopene appears to be a very promising antioxidant in the management of oral submucous fibrosis, both in clinical and symptomatic improvement.
RESUMO
AIM: This study aimed at evaluating and comparing the bond strength of stainless steel brackets bonded with multiple orthodontic adhesives. MATERIALS AND METHODS: About 60 premolars extracted to create space during orthodontic treatment were included in the present study. Premolar stainless steel brackets of size 0.022" slot with the surface area of bracket base of 11.15 mm2 were used. The premolars were divided randomly into three groups of 20 in each. Group I: Conventional Acid Etching (Transbond XT); group II: Seventh-generation adhesive materials (Xeno V); and group III: Flowable composite (Filtek Z350 XT). Calculation of Adhesive Remnant Index (ARI) was done and shear bond strength was assessed. The probability level of 0.05 was considered as clinically significant. RESULTS: The shear bond strength was highest in group II (17.46 ± 1.36), which was followed by group I (15.33 ± 2.78) and the least was shown by group III (13.96 ± 1.44). A statistically significant difference was found between group I vs II, group II vs III, and group III vs II. Utmost prevalence of about 35% was found in Transbond XT with an ARI score of 3 (followed by all adhesive left on the tooth), Filtek Z350 XT with 20%, and the least was found with Xeno V, about 5%. The probability was found to be p = 0.025 among different groups, which is statistically significant according to chi-square test. CONCLUSION: The study concluded that the adhesive materials of the seventh generation showed higher shear bond strength than that of the flowable composite and conventional acid etching. The ARI indicated that a minimum amount of the residual adhesive was found on the surface of the enamel after debonding. CLINICAL SIGNIFICANCE: This study helps orthodontists to select appropriate adhesive and orthodontic brackets for the benefit of the patient and to distinguish the distribution of stress homogeneously within the layer of cement while loading and subsequently minimizing the damage to the enamel during the debonding of orthodontic brackets.
