1.
ACS Omega
; 6(44): 29993-30002, 2021 Nov 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34778670
RESUMO
Levonadifloxacin (WCK 771) is a novel broad-spectrum anti-methicillin-resistant Staphylococcus aureus (MRSA) agent recently launched in India. Five process impurities and one degradation impurity were synthesized as reference standards for their quantification by high-performance liquid chromatography (HPLC) methodology in drug substance and drug product. These compounds are not easily commercially available. The synthesis and characterization of these impurities are discussed in detail.