RESUMO
Immunoglobulins A, E and G were studied in serum and nasal secretion from patients with allergic rhinitis, chronic rhinitis and aspirin hypersensitivity, and normal controls. The allergic patients differed from the other groups in having higher IgE values, both in serum and in nasal secretion. The patients with aspirin hypersensitivity did not differ from the control group regarding the IgE values. No difference between the groups was found with respect to IgA and IgG. The results indicate that reaginic antibodies are not involved in causing aspirin hypersensitivity.
Assuntos
Hipersensibilidade a Drogas/imunologia , Imunoglobulinas/análise , Rinite Alérgica Sazonal/imunologia , Adulto , Idoso , Aspirina , Feminino , Humanos , Imunoglobulina A/análise , Imunoglobulina E/análise , Imunoglobulina G/análise , Masculino , Pessoa de Meia-Idade , Mucosa Nasal/metabolismoRESUMO
Clinical study of an insulin-like compound obtained from vegetable source (vegetable insulin) was carried out on nine patients with diabetes mellitus. The active hypoglycaemic principle, purified protein extract, was obtained from fruits as well as from tissue cultures of the plant Momordica charantia L. This extract was homologous to insulin obtained from animal pancreas. It showed a consistent hypoglycaemic effect in patients with diabetes mellitus. The average fall in blood sugar level at the peak effect of vegetable insulin was found to be statistically significant. The onset of action was within 30-60 min with the peak effect six hours after the administration of the dose of plant insulin. No hypersensitivity reaction to this extract was observed in the group of patients studied.
Assuntos
Diabetes Mellitus/tratamento farmacológico , Insulina/análogos & derivados , Extratos Vegetais/química , Adolescente , Adulto , Glicemia/análise , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto JovemRESUMO
Eosinophil count in peripheral blood, nasal secretion and nasal mucosa were studied in 20 controls and 38 patients with different patterns of allergic rhinits. Secretion and tissue eosinophilia were pathologically high in a greater number of patients than peripheral blood eosinophilia. This trend was seen in all patterns of allergic rhinitis but was more evident in seasonal allergic rhinitis. The conclusion was reached that examination of local site and local secretions for eosinophilia is helpful in the diagnosis and differential diagnosis of allergic rhinitis.
