Crystal structures of (12E)-12-(4-benzyl-idene)-7,7,16-trimethyl-3-(4-methyl-phen-yl)-1-oxa-16-aza-tetra-cyclo-[11.2.1.02,11.04,9]hexa-deca-2(11),4(9)-dien-5-one and (12E)-12-(4-bromo-benzyl-idene)-73-(4-bromo-phen-yl)-,7,16-trimethyl-10-oxa-16-aza-tetra-cyclo-[11.2.1.02,11.04,9]hexa-deca-2(11),4(9)-dien-5-one.

The title compounds, C32H35NO2, (I), and C30H29Br2NO2, (II), differ by the presence of a bromine atom instead of a methyl atom in the para position of two benzene rings of compound (II). The two compounds have a structural overlap r.m.s. deviation of 0.27 Å. The pyran and seven-membered cyclo-heptene rings in both structures adopt boat and boat-sofa conformations, respectively. Intra- and inter-molecular C-H⋯O hydrogen bonds are responsible for the consolidation of the crystal packing of both mol-ecules. In addition to this, weak C-H⋯π inter-actions are also observed. The inter-molecular inter-actions were qu-anti-fied and analysed using Hirshfeld surface analysis.

(E)-5-(4-Methyl-benzyl-idene)-1-phenyl-4,5,6,7-tetra-hydro-1H-indazol-4-one.

In the title compound, C21H18N2O, the non-aromatic six-membered ring adopts a distorted envelope conformation with one of the methyl-ene-C atoms being the flap atom. The dihedral angle between the phenyl and 4-tolyl rings is 75.3 (1)°. The 1,2-diazole ring forms dihedral angles of 41.9 (1) and 65.5 (1)° with the phenyl and 4-tolyl rings, respectively. In the crystal, stabilizing C-H⋯O, C-H⋯π and π-π inter-actions are evident. The calculated Hirshfeld surfaces highlight the prominent role of C-H⋯O inter-actions (8.6%), along with H⋯H (51.7%) and C⋯H/H⋯C (29.2%) surface contacts.

(E)-5-(4-Chloro-benzyl-idene)-1-phenyl-4,5,6,7-tetra-hydro-1H-indazol-4-one: crystal structure and Hirshfeld surface analysis.

In the title compound, C20H15ClN2O, the non-aromatic six-membered ring adopts a distorted envelope conformation with methyl-ene-C atom nearest to the five-membered ring being the flap atom. The dihedral angle between the phenyl and chloro-benzene rings is 74.5 (1)°. The heterocyclic ring forms dihedral angles of 37.9 (1) and 64.3 (1)° with the phenyl and chloro-benzene rings, respectively. In the crystal, weak C-H⋯O inter-actions feature predominantly within the three-dimensional architecture. The inter-molecular inter-actions are further analysed with the calculation of the Hirshfeld surfaces highlighting the prominent role of C-H⋯O inter-actions, along with H⋯H (36.8%) and C⋯H/H⋯C (26.5%) contacts.

Knowledge and attitude towards infant feeding among rural health personnel.

PIP: The knowledge and attitude towards infant feeding practices were studied among such health personnel as doctors, nurses, and dais who provided maternal and child health services in rural areas. The health personnel were not fully aware of the proper infant feeding practices. Almost 17.5% of these respondents advised that breastfeeding should be stopped by 1 year of age and 75.1% advised the use of diluted milk as supplementary feeding. These inappropriate suggestions to an illiterate rural population could be disastrous. The study highlights the needs for continuing medical education and for the stepping-up of pediatric training in undergraduate coursework in this area.^ieng