RESUMO
A novel gold (I)-catalyzed synthetic strategy has been achieved for an efficient construction of indenylidene derivatives from substituted 1,6-diynes. This reaction describes the unique reactivity of gold catalysis in facilitating the intramolecular [3,3]-sigmatropic rearrangement, 5-exo dig cyclization followed by 1,5-migration of acryl group, resulting in the formation of substituted indenylidenes. Various substituted indenylidenes were successfully synthesized with up to 92 % yields. In this protocol, two new C-C bonds were sequentially formed atom economically in one pot.
RESUMO
An efficient metal-free, additive-free synthetic method was developed to access benzooxepino-fused pyrrole derivatives from alkynyl substituted aziridines. In this organic transformation, two new C-C bonds were formed via initial cleavage of C-C bond of aziridine ring by inâ situ generated azomethine ylides. Moderate to excellent yields of benzooxepino-fused pyrroles were obtained atom economically in the presence of t-BuOH in one-pot.
RESUMO
Gold(I)-catalyzed efficient synthetic transformation was achieved to access the tetrahydrobenzo[h]cyclopropa[c]chromenes from allyl-substituted 1,6-diynes. Cyclopropane-fused tetrahydrobenzochromenes were obtained regioselectively in ≤92% yields. In this atom-economic organic transformation, three new C-C bonds were formed sequentially in one pot.
RESUMO
An efficient gold-catalyzed formation of 6-hydroxyindoles from substituted alkynylcyclohexadienones and amines have been developed. In this reaction two new C-N bonds were formed, and moderate to very good yields of the 6-hydroxyindole derivatives were obtained in one pot. This organic transformation tolerates a range of substituted alkynylcyclohexadienones and amines, which resulted in 6-hydroxyindole derivatives selectively.
