1.
Angew Chem Int Ed Engl
; 58(37): 13039-13043, 2019 Sep 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31237988
RESUMO
Reported is an iridium catalyst for ortho-selective C-H borylation of challenging secondary aromatic amide substrates, and the regioselectivity is controlled by hydrogen-bond interactions. The BAIPy-Ir catalyst forms three hydrogen bonds with the substrate during the crucial activation step, and allows ortho-C-H borylation with high selectivity. The catalyst displays unprecedented orthoâ selectivities for a wide variety of substrates that differ in electronic and steric properties, and the catalyst tolerates various functional groups. The regioselective C-H borylation catalyst is readily accessible and converts substrates on gram scale with high selectivity and conversion.