RESUMO
OBJECTIVE: The aim of this study was to evaluate the prognostic value of a novel scoring system, based on Ddimer, total cholesterol, high-sensitivity cardiac troponin T (hs-cTnT), and serum albumin levels, in patients with heart failure. METHODS: A total of 221 patients diagnosed with heart failure between May 2016 to January 2020 were enrolled in this retrospective study. The prognostic significance of the biomarkers Ddimer, total cholesterol, hs-cTnT, and serum albumin was determined with univariate and multivariate Cox proportional hazard models. A novel prognostic score based on these predictors was established. The Kaplan-Meier method and log-rank test were used to compare the adverse outcomes of patients in different risk groups. RESULT: Results from univariate and multivariate analyses showed that high Ddimer, low serum albumin, high hs-cTnT, and low total cholesterol levels were independent prognostic factors for adverse outcomes (D-dimer >0.63â¯mg/l, HRâ¯= 1.84, 95% CIâ¯= 1.16-2.94, pâ¯= 0.010; serum albumin >34â¯g/l, HRâ¯= 0.67, 95% CIâ¯= 0.45-0.99, pâ¯= 0.046; hs-cTnT >24.06â¯pg/ml, HRâ¯= 1.65, 95% CIâ¯= 1.08-2.53, pâ¯= 0.020; total cholesterol >3.68â¯mmol/l, HRâ¯= 0.63, 95% CIâ¯= 0.43-0.92, pâ¯= 0.017). Moreover, all the patients were stratified into low-risk or high-risk group according to a scoring system based on these four markers. Kaplan-Meier analyses demonstrated that patients in the high-risk group were more prone to having adverse outcomes compared with patients in the low-risk group. CONCLUSION: Ddimer, total cholesterol, hs-cTnT, and serum albumin levels were independent prognostic factors in the setting of heart failure. A novel and comprehensive scoring system based on these biomarkers is an easily available and effective tool for predicting the adverse outcomes of patients with heart failure.
Assuntos
Insuficiência Cardíaca , Troponina T , Biomarcadores , Ácido Edético/análogos & derivados , Insuficiência Cardíaca/diagnóstico , Humanos , Prognóstico , Estudos RetrospectivosRESUMO
Aim: To evaluate the clinical value of plasma D-dimer/fibrinogen ratio (DFR) in patients hospitalized for heart failure (HF). Methods: Clinical data of 235 patients were retrospectively analyzed. Kaplan-Meier method and Cox regression analysis were used to identify significant prognosticators. Results: The Kaplan-Meier analysis showed that a higher DFR level was significantly associated with an increase in the end point outcomes, including HF readmission, thrombotic events and death (log-rank test: p < 0.001). The multivariate Cox regression analysis showed that the high tertile of DFR was significantly associated with the study end points (HR: 2.18; 95% CI: 1.31-3.62; p = 0.003), compared with the low tertile. Conclusion: DFR is a reliable prognostic indicator for patients hospitalized for HF.