1.
Eur J Clin Pharmacol
; 47(6): 503-5, 1995.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7768252
RESUMO
The genetic polymorphism of drug oxidation mediated by cytochrome P450IID6 (CYP2D6) was determined in 154 Polish volunteers using debrisoquine as the test substance. The results showed a bimodal distribution of the debrisoquine metabolic ratio (MR). Nine persons (5.8%) with MR > 12.6 were classified as poor metabolisers (gene frequency 0.242), which is in substantial agreement with the data reported for other Caucasian populations.