A retrospective comparison of mechanically vs. kinematically aligned unicompartmental knee arthroplasties.

Background: Unicompartmental Knee Arthroplasties (UKAs) treat unicompartmental arthritic degeneration. Traditionally, they are placed in a mechanical alignment with bone cuts perpendicular to the leg's mechanical axis. Kinematic alignment, an alternative, considers the patient's pre-arthritic alignment. Methods: A retrospective study at Medstar Washington Hospital Center from 2015 to 2022 identified 72 UKA patients. Among them, 53 had mechanical alignments, and 20 had kinematic alignments. Using the Forgotten Joint Score (FJS) and Oxford Knee Score (OKS), Patient Reported Outcome Measures for these surgeries were recorded. Individuals were additionally analyzed post-surgically for Coronal Plane Alignment of the Knee (CPAK). Analysis was performed within the post-operative joint imaging, where mechanical medial proximal tibial angle (MPTA) and lateral distal femoral angle (LDFA) were measured. The arithmetic hip knee ankle angle (aHKA) and joint line obliquity (JLO) were calculated according to the results of MPTA-LDFA and MPTA + LDFA respectively and grouped in accordance with the CPAK classification. Results: Overall, there was a statistically significant response rate of 51% (>50%). According to the FJS, the mechanical cohort averaged a score of 39.1 (±33.8), while the kinematical cohort averaged 56.5 (±35.2). A two-sample t-test of this data demonstrated a statistically insignificant p-value of 0.1537. According to the OKS, the mechanical cohort averaged a score of 29.1 (±10) and the kinematical cohort averaged 38.4 (±8). A two-sample t-test of this data demonstrated a statistically significant p-value of <0.001. Of note, 7 patients had to undergo revisions in the mechanical alignment cohort compared to 0 in the kinematic alignment cohort due to aseptic loosening. Conclusion: This study demonstrates the potential benefit in patient outcomes for individuals who undergo a kinematic rather than mechanical alignment of their UKAs. The results of the CPAK data with the significance of LDFA are consistent with the goals of the mechanical and kinematic alignment respectively.

Trends in amphetamine prescriptions given at discharge in emergency departments: A national analysis (2012-2019).

OBJECTIVES: In parallel with the opioid epidemic, there has been a resurgence in abuse, medical complications, and deaths related to amphetamines. The opioid epidemic began with increasing rates of prescription products that evolved overtime to include heroin and more recently, fentanyl analogues. Current trends in amphetamine prescriptions are less well described. We sought to determine if there has been a change in amphetamine prescriptions given at discharge in U.S. emergency departments (EDs) in recent years. METHODS: We conducted a retrospective review of data provided by the National Hospital Ambulatory Medical Care Survey (NHAMCS) from 2012 to 2019. We computed total number of visits that were given amphetamine prescriptions (amphetamine salts, methylphenidate derivatives, and dexmethylphenidate) at discharge for each year. We computed the total number and rate of visits (of all ED visits) that had both amphetamines and opioids prescribed at discharge over the years. We computed data normality using Shapiro Wilke's test and used descriptive statistics such as mean to describe the data distribution as applicable. We used spearman's rho (SR) or pearson's correlation (PC) as applicable to describe trends in data. All p-values were one-tailed and were reported at a 0.05 significance level. All analyses were conducted in IBM SPSS version 28. RESULTS/FINDINGS: From 2012 to 2019, there were an estimated 817,895 ED visits where an amphetamine prescription was given at discharge, with an overall strong increase in rate over time (SR = 0.71, p = 0.02). At the beginning of the study period (2012) there were 83,503 (0.06%) visits and in 2019 there were 186,539 (0.12%) visits (123% absolute increase). On average, there were 102,237 (SD: 52,725) visits with discharge amphetamine prescriptions per year. There was a strong, linear increase in number of visits that involved a discharge amphetamine salt prescription (PC = 0.92, p = 0.001). In 2012, there were a total of 23,676 visits and in 2019, a total of 124,773 visits (427% increase). There was no trend in visits where both an amphetamine and opioid were prescribed (PC: 0.61, p = 0.06). CONCLUSION: There have been increases in discharge prescriptions for amphetamines in the ED over time. This was largely driven by prescriptions for amphetamine salts. Future research initiatives should continue to monitor this trend and in prescriptions and associated abuse in the setting of rising amphetamine abuse.

Brescia-Cimino AV Fistula Complicated by Steal Syndrome.

The Brescia-Cimino AV fistula is most commonly performed and rarely associated with steal syndrome. A case is presented with details regarding its correction.

Iatrogenic Interval Gangrene of the Thigh.

Interval gangrene of the thigh is an extremely rare complication in vascular surgery. Most cases have reported interval gangrene of the calf as a consequence of a distal bypass procedure, with little documentation of interval thigh gangrene occurring after endovascular intervention. The present case suggests that in the process of placing multiple-level covered and bare metal stents in the iliac, superficial femoral, and popliteal arteries, interval gangrene of the thigh must be considered as a potential, albeit rare, complication. Preservation of pelvic and profunda femoris flow to the thigh is imperative to prevent the development of interval tissue loss. This case demonstrates the importance of maintaining profunda femoris circulation, especially in patients with significant vascular comorbidities. Patient consent was obtained for details of the case to be used for publication.