RESUMO
Enzymes of biotransformation system involved in the metabolism of exogenous and endogenous compounds are effective mechanism of protection from negative environmental factors. Decreasing activity or insufficient synthesis of biotransformation system enzymes caused by genetic polymorphism form the risk of various complex diseases, including atopic. Using allele-specific hybridization on the biochip the frequencies of xenobiotic-metabolizing gene polymorphisms in Russian children with bronchial asthma, allergic rhinitisand healthy donors from the Republic of Bashkortostan have been determined. The analysis of polymorphisms in CYP1A1, GSTT1, GSTM1, NAT2, MTHFR, CYP2C9 and CYP2C19 genes didn't reveal any association with atopic diseases. The frequencies of CYP2D6*1934G/G genotype and CYP2D6*1934G allele were significantly higher among boys with rhinitis symptoms than in control group.
Assuntos
Exposição Ambiental/efeitos adversos , Oxirredutases/genética , Polimorfismo Genético , Rinite Alérgica Perene/genética , Xenobióticos/efeitos adversos , Adolescente , Alelos , Bashkiria , Criança , Pré-Escolar , Feminino , Frequência do Gene/genética , Humanos , Lactente , Masculino , Rinite Alérgica Perene/induzido quimicamente , Rinite Alérgica Perene/enzimologia , Fatores SexuaisRESUMO
The article presents data on influence of technogenic environmental pollution and parents' occupational hazards on sex-matched physical development of preschoolers, their endocrine balance and antioxidant system. The identified features of physical development, endocrine state and antioxidant system prove higher sensitivity of girls to chemical hazards. Significance of the studied parameters necessitate their use in biologic and ecologic monitoring.
