RESUMO
Data about the expression of the fragile site at Xq27.3 from 74 daughters of normal transmitting males (NTMs) were collected from 7 different genetic centers. The majority (85.1%) of these obligate female carriers did not show any cytogenetic expression of fra-X. The remaining 14.9% of these females had frequencies below 3%. In cases with a frequency below 3% of fra-X, a "premutated"/"non imprinted" state of a female carrier should be considered. The results of this collaborative study are in accordance with data from DNA studies taking the premutation model into account.
Assuntos
Síndrome do Cromossomo X Frágil/genética , Triagem de Portadores Genéticos , Mutação/genética , Fenótipo , Feminino , Síndrome do Cromossomo X Frágil/prevenção & controle , Frequência do Gene/genética , Humanos , Masculino , Modelos Genéticos , Polimorfismo de Fragmento de RestriçãoRESUMO
The present paper presents an existential analysis of the condition of rural India in reference to water supply and pollution and the resulting health hazard mainly due to high content of chloride, nitrate, sulphate and the hardness. From the view-point of public health, the prevailing sources of water supply i.e. wells, streams and reservoirs, are the subject of contamination as they are exposed to pollution from surface drainage, household and animal refuse, as well as from the uncleaned buckets used for carrying water. In reference to bacterial checkup of athe well water awareness among villagers is necessary, so that the government authorities may provide good quality drinking/potable water through their schemes.
Assuntos
Doenças Transmissíveis/transmissão , Poluição da Água/análise , Abastecimento de Água/análise , Cloretos/análise , Índia , Nitratos/análise , Saúde Pública , População Rural , Sulfatos/análise , Microbiologia da Água , Abastecimento de Água/normasRESUMO
PIP: The attempt was made to determine whether there has been a statistically significant change in the incidence of strokes among women of childbearing age in Bakersfield, California since oral contraceptives (OCs) came into general use in 1960 and whether the change in this incidence is similar to that determined by the staff of the Mayo Clinic in its study of Rochester, Minnesota. Results obtained for each city reveal that both the number and the incidence of strokes were greater during the 1st study period than they were during the 2nd. The incidence of strokes was markedly greater in Rochester than it was in Bakersfield during the 1st study period, but the incidence in each city during the 2nd period was about the same. It is concluded that in neither Rochester nor Bakersfield did the number or incidence of strokes among women of childbearing age increase after OC came into general use. In actuality, strokes decreased.^ieng
Assuntos
Transtornos Cerebrovasculares/epidemiologia , Anticoncepcionais Orais/efeitos adversos , California , Transtornos Cerebrovasculares/induzido quimicamente , Métodos Epidemiológicos , Feminino , Humanos , Minnesota , Gravidez , Fatores Sexuais , Estatística como Assunto/métodosRESUMO
PIP: This criticizes published data in a recent article on oral contraception and increased risk of cerebral ischemia or thrombosis. Data appear to establish a statistically significant increased risk of thrombotic and hemorrhagic stroke among young women using oral contraceptives. This risk is believed exaggerated. In the 98 case-controlled pairs there were 10 patients with a thrombotic times greater among users as among nonusers. The authors mathematically analyze why they feel the risk was improperly computed. Also the relative risk of stroke by age and race are considered to be improperly stated.^ieng
