MORPHOMETRIC FEATURES OF THE STRUCTURAL COMPONENTS OF THE HEMOMICROCIRCULATORY BED IN THE PERIVULNAR REGION OF THE CAECUM IN WOUND DEFECT SUTURED WITH POLYFILAMENT SUTURE MATERIAL.

OBJECTIVE: The aim: The study focuses on the morphometric features specification concerning the structural components of the hemomicrocirculatory bed of the perivulnar region of the cecum in rabbits when suturing a wound defect with synthetic polyfilament surgical suture Vicryl. PATIENTS AND METHODS: Materials and methods: The research was carried out on rabbits (n = 30: 5 animals made up the control group and 25 animals made up the experimental group) and included surgery based on the method of surgical intervention on the large intestine patented by the authors, which was performed in the conditions of the operating room at the Department of Clinical Anatomy and Operative Surgery. When determining the main morphometric parameters, we took biopsy specimens of the cecum and used paraffin and epoxy resin embedding considering the generally accepted methods. RESULTS: Results: The study determined that the implantation of Vicryl surgical suture material in the tissues of the cecum became a trigger for the formation of active inflammatory focus and occurrence of leukocyte infiltrate in the perivulnar region. CONCLUSION: Conclusions: Arterioles, as a resistive link, capillaries, as an exchange link and venules, as a capacitive link in the hemomicrocirculatory bed, actively participate in response to the inflammatory process and formation of a connective tissue scar. The process of structural organization of microvessels begins in the formed granulation tissue in the perivulnar region of the cecum starting from the 14th day of the experiment.

The use of immunohistochemical methods in the study of morphofunctional features of the human paranasal sinuses: literature review.

OBJECTIVE: Introduction:Chronic inflammatory diseases of the mucous membrane of the nose, paranasal sinuses, and pharynx are the most widespread pathology of the upper airways. The thorough study of the features of the organization of local immune protection of the mucous membrane of the paranasal sinuses is crucial for the deep understanding of the causes of the onset and development of this and other pathologies of the paranasal sinuses, the choice of methods of diagnostics and treatment. Consequently, immunohistochemical studies are of great potential and have become preferable for great number of researchers. The aim: The paper was aimed at the analysis of the publications on the use of immunohistochemical methods in the study of the structural and functional features of the paranasal sinuses. PATIENTS AND METHODS: Materials and methods: The bibliosemantic method has been used during the study. Findings of the current research works on the use of immunohistochemical methods in the study of the paranasal sinuses have been analyzed. RESULTS: Review:The findings of the analysis shows that the use of immunohistochemical methods in the otorhinolaryngology is becoming more and more popular in the study of both morphofunctional features of the paranasal sinuses and in various experimental studies. CONCLUSION: Conclusion: The use of immunohistochemical methods in the study of the paranasal sinuses in both clinical otorhinolaryngology and theoretical morphology is relevant to date and is considered reasonable and perspective.