Hypohidrosis in Individuals with Exertional Heat Injury: A Prospective Open Cohort Study.

BACKGROUND: Hypohidrosis is a risk factor for developing heat-related illnesses. OBJECTIVE: To determine the prevalence of hypohidrosis in heat injury. METHODS: Soldiers from the Singapore Armed Forces who developed heat injury between January 1, 2012 and December 31, 2013 were invited to participate in the study. Subjects were induced to sweat through exercising in a temperature- and humidity-regulated room, and then atomized starch-iodine powder was administered over their whole body to detect hypohidrosis. If this was found to be present, investigations to elucidate the cause of anhidrosis were performed. RESULTS: Out of 65 males, 30 consented to participation. One was excluded because an exogenous cause resulted in heat injury. Nine (31%) demonstrated hypohidrosis. Of these, 1 (11%) had miliaria profunda, 2 (22%) had acquired idiopathic generalized anhidrosis and 6 (67%) manifested a new phenotype which we termed acquired symmetrical hypohidrosis (ASH). CONCLUSION: Thirty-one percent of healthy soldiers who developed heat injury had hypohidrosis. Concurrently, a new clinical phenotype of ASH was identified.

Generalized ligamentous laxity may be a predisposing factor for musculoskeletal injuries.

OBJECTIVES: The aim of this study is to determine if generalized ligamentous laxity may be a predisposing factor for musculoskeletal injuries in young males. We hypothesized that generalized ligamentous laxity would be more common in individuals with musculoskeletal injuries compared with controls. DESIGN: Prospective Age- and Gender-matched Case-Control Study examined generalized ligamentous laxity in 100 consecutive individuals aged 18-25 who reported with musculoskeletal injuries to a primary healthcare center in the military. The Beighton score was used to measure joint laxity, which was determined to be present by overall scores equal to or exceeding 4. The control group comprised 100 age- and gender-matched individuals without any musculoskeletal injuries or complaints. The prevalence of generalized ligamentous laxity was then compared between cases and controls. Subgroup analyses were also performed to evaluate the epidemiology of injury within the cases. METHODS: This prospective case-control study examined generalized ligamentous laxity in 100 consecutive individuals aged 18-25 who reported with musculoskeletal injuries to a primary healthcare center in the military. The Beighton score was used to measure joint laxity, which was determined to be present by overall scores equal to or exceeding 4. The control group comprised 100 age- and gender-matched individuals without any musculoskeletal injuries or complaints. The prevalence of generalized ligamentous laxity was then compared between cases and controls. RESULTS: Generalized ligamentous laxity was present in 12% of the cases compared with 4% of controls Clearer to be presented as (P-value: 0.043). Individuals who presented with musculoskeletal injuries were 3.35 times more likely to have generalized ligamentous laxity as compared to controls. Lower limb injuries were more common than upper limb injuries amongst the cases. CONCLUSIONS: Generalized ligamentous laxity was more common in individuals who presented with a musculoskeletal injury. Hence, it may be a predisposing factor for musculoskeletal injuries.