RESUMO
One hundred sixteen patients with granuloma annulare and necrobiosis lipoidica were studied. The relationship of these two disorders with diabetes mellitus suggests that atypical granuloma annulare could be linked to necrobiosis lipoidica, toward which it progresses.
Assuntos
Complicações do Diabetes , Granuloma/complicações , Necrobiose Lipoídica/complicações , Adolescente , Adulto , Idoso , Metabolismo dos Carboidratos , Criança , Pré-Escolar , Feminino , Granuloma/etiologia , Granuloma/patologia , Granuloma/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Necrobiose Lipoídica/etiologia , Necrobiose Lipoídica/patologiaAssuntos
Diabetes Mellitus/enzimologia , Muramidase/metabolismo , Pele/enzimologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Two kinds of secretions, both merocrine and apocrine, have been detected in the serous adenomeres of the human olfactory glands. While the low-density vesicles secrete their products into the glandular lumen by a merocrine way (exocytosis), the electron-dense granules are produced by an apocrine mechanism.
Assuntos
Glândulas Apócrinas/metabolismo , Mucosa Olfatória/metabolismo , Glândulas Sudoríparas/metabolismo , Glândulas Apócrinas/citologia , Humanos , Mucosa Olfatória/citologiaAssuntos
Resinas Acrílicas , Filtração/instrumentação , Diálise Renal/métodos , Dermatopatias/terapia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Dermatite Seborreica/patologia , Ceratose/patologia , Adulto , Humanos , Masculino , População BrancaAssuntos
Diabetes Mellitus/metabolismo , Glucose/análise , Pele/análise , Glicemia/análise , Feminino , Humanos , MasculinoAssuntos
Doenças do Pé/microbiologia , Micetoma/patologia , Idoso , Feminino , Humanos , Itália , Micetoma/epidemiologiaRESUMO
The activity of phospholipase A2 was tested both in rat skin and human psoriatic skin before and after systemic treatment with a retinoic acid derivative: RO 10-9359. An increase of activity was found in the rat skin homogenates when the animals were treated with 3 mg/kg/day of the drug for 8 days, while no effect was found following treatment with 1.5 mg/kg/day for 10 days. On the contrary a decrease of this activity was found in homogenates from both involved and uninvolved skin of psoriatic patients after systemic treatment with 1-1.5 mg/kg/day for 10 days. These different results are discussed also in the light of the clinical effect of RO 10-9359 on psoriasis.
Assuntos
Etretinato/farmacologia , Fosfolipases A/metabolismo , Fosfolipases/metabolismo , Psoríase/enzimologia , Pele/enzimologia , Tretinoína/análogos & derivados , Adulto , Idoso , Animais , Ácido Araquidônico , Ácidos Araquidônicos/metabolismo , Humanos , Técnicas In Vitro , Metabolismo dos Lipídeos , Masculino , Pessoa de Meia-Idade , Mitocôndrias Hepáticas/enzimologia , Fosfolipases A2 , Ratos , Ratos EndogâmicosRESUMO
The therapeutic results obtained with twice daily medication with 3% hydrocortisone bendazac ester cream are indicated. This therapy was found to be effective particularly in photodermatoses radiation dermatitis and superficial vascular skin disorders. Moreover, it is also very useful for varicose veins and phlebitis, photoactive eczema and burns, since it can limit the necrotic evolution, correct excessive granulation tissue formation and control the tendency towards the development of keloids.
