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1.
BMC Pulm Med ; 20(1): 17, 2020 01 21.
Artigo em Inglês | MEDLINE | ID: mdl-31964360

RESUMO

Following publication of the original article [1], the authors flagged that the article had published with an error in 'Table 1'.

2.
BMC Pulm Med ; 19(1): 245, 2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31842840

RESUMO

BACKGROUND: Preterm newborns typically require supplemental oxygen but hyperoxic conditions also damage the premature lung. Oxygen-induced lung damages are mainly studied in newborn mouse models using oxygen concentrations above 75% and looking at short-term effects. Therefore, we aimed at the investigation of long-term effects and their dependency on different oxygen concentrations. METHODS: Newborn mice were exposed to moderate vs. severe hyperoxic air conditions (50 vs. 75% O2) for 14 days followed by a longer period of normoxic conditions. Lung-related parameters were collected at an age of 60 or 120 days. RESULTS: Severe hyperoxia caused lower alveolar density, enlargement of parenchymal air spaces and fragmented elastic fibers as well as higher lung compliance with peak airflow limitations and higher sensitivity to ventilation-mediated damages in later life. However, these long-term lung structural and functional changes did not restrict the voluntary physical activity. Also, they were not accompanied by ongoing inflammatory processes, increased formation of reactive oxygen species (ROS) or altered expressions of antioxidant enzymes (superoxide dismutases, catalase) and lung elasticity-relevant proteins (elastin, pro-surfactant proteins) in adulthood. In contrast to severe hyperoxia, moderate hyperoxia was less lung damaging but also not free of long-term effects (higher lung compliance without peak airflow limitations, increased ROS formation). CONCLUSIONS: Severe but not moderate neonatal hyperoxia causes emphysematous lungs without persisting oxidative stress and inflammation in adulthood. As the existing fragmentation of the elastic fibers seems to play a pivotal role, it indicates the usefulness of elastin-protecting compounds in the reduction of long-term oxygen-related lung damages.


Assuntos
Hiperóxia/fisiopatologia , Estresse Oxidativo , Oxigênio/efeitos adversos , Alvéolos Pulmonares/fisiopatologia , Enfisema Pulmonar/fisiopatologia , Animais , Animais Recém-Nascidos , Antioxidantes/farmacologia , Modelos Animais de Doenças , Feminino , Inflamação/fisiopatologia , Pulmão/fisiopatologia , Camundongos , Camundongos Endogâmicos C57BL , Oxigênio/farmacologia , Fenótipo , Alvéolos Pulmonares/metabolismo , Espécies Reativas de Oxigênio/metabolismo
3.
Exp Gerontol ; 87(Pt B): 139-147, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-27108181

RESUMO

Laboratory mice of both sexes having free access to running wheels are commonly used to study mechanisms underlying the beneficial effects of physical exercise on health and aging in human. However, comparative wheel-running activity profiles of male and female mice for a long period of time in which increasing age plays an additional role are unknown. Therefore, we permanently recorded the wheel-running activity (i.e., total distance, median velocity, time of breaks) of female and male mice until 9months of age. Our records indicated higher wheel-running distances for females than males which were highest in 2-month-old mice. This was mainly reached by higher running velocities of the females and not by longer running times. However, the sex-related differences declined in parallel to the age-associated reduction in wheel-running activities. Female mice also showed more variances between the weekly running distances than males, which were recorded most often for females being 4-6months old but not older. Additional records of 24-month-old mice of both sexes indicated highly reduced wheel-running activities at old age. Surprisingly, this reduction at old age resulted mainly from lower running velocities and not from shorter running times. Old mice also differed in their course of night activity which peaked later compared to younger mice. In summary, we demonstrated the influence of sex on the age-dependent activity profile of mice which is somewhat contrasting to humans, and this has to be considered when transferring exercise-mediated mechanism from mouse to human.


Assuntos
Envelhecimento/fisiologia , Corrida/fisiologia , Fatores Sexuais , Animais , Feminino , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Condicionamento Físico Animal , Seleção Genética
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