RESUMO
Four compliance strategies were compared with education alone to investigate their impact on the control of high blood pressure. One hundred twelve subjects with documented high blood pressure were randomly assigned to receive education alone, home blood pressure monitoring, contracts, pill packs, or a combination of techniques. Groups were similar in terms of age, sex, race, initial blood pressure, and medications. At the end of the year, there was no significant change in blood pressure for the group that received education alone (-3/-1 mm Hg). There was a statistically significant change in both systolic and diastolic blood pressure for all compliance groups (-17/-10 mm Hg). Information from compliance questionnaires adds further support to the observation that education alone does not influence compliance while the specific techniques studied did improve compliance. The study was too small to show any difference among techniques.
Assuntos
Hipertensão/terapia , Cooperação do Paciente , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea , Humanos , Hipertensão/tratamento farmacológico , Hipertensão/fisiopatologia , Monitorização Fisiológica , Educação de Pacientes como Assunto , AutocuidadoRESUMO
Extraovarian estrogen production was studied in an obese young woman with pathologically confirmed mosaic Turner syndrome and pseudotumor cerebri. Diet plus enough dexamethasone to suppress adrenal steroidogenesis promptly lowered cerebrospinal fluid testosterone. Estrone was detected in cerebrospinal fluid before and after but not during dexamethasone treatment. Extraovarian estrogen probably produces the menstrual irregularities of obese young women with pseudotumor cerebri and may be involved in the pathogenesis of that syndrome.
Assuntos
Obesidade/metabolismo , Pseudotumor Cerebral/metabolismo , Corticosteroides/uso terapêutico , Adulto , Androstenodiona/metabolismo , Estrogênios/metabolismo , Estrona/líquido cefalorraquidiano , Estrona/metabolismo , Feminino , Humanos , Menstruação , Obesidade/complicações , Obesidade/terapia , Pseudotumor Cerebral/complicações , Pseudotumor Cerebral/tratamento farmacológico , Síndrome de Turner/complicaçõesRESUMO
The effects of the combination of glucocorticoids and calcitonin on serum calcium levels were compared with the responses to calcitonin alone in 14 patients with malignant disease and hypercalcemia. The serum calcium concentrations of those patients treated with calcitonin alone returned to pretreatment concentrations within 48 hours, whereas those treated with the combination of calcitonin and glucocorticoids maintained the lower serum calcium concentrations for more than 4 days. These results suggest that the combination of calcitonin and glucocorticoids is a rapidly effective form of medical treatment for hypercalcemia and that glucocorticoids help to maintain the acute response to calcitonin in patients with hypercalcemia.
