Metastatic malignant melanoma: A case of metastasis from foot to mandibular anterior region.

Metastatic malignant melanoma (MMM) of the oral cavity is extremely rare which generally presents in the setting of disseminated disease and have extremely poor prognosis. The most common site for MMM in the oral cavity is tongue followed by buccal mucosa for soft-tissue lesions and posterior mandible for bone involving lesions. Primary tumor sites of oral MMM are usually cutaneous lesions of the trunk, head and neck, limbs, and nasal septum mucosa. Patients bearing this diagnosis face median survival time of approximately 9 months with a probability of surviving 5 years after the initial presentation is <5%; hence, an early detection and treatment for the primary and metastatic lesion is crucial. Here, we present an unusual case of MMM of oral cavity involving gingiva and alveolar bone of the mandibular anterior region metastasizing from a primary lesion on the foot.

Oral submucous fibrosis: A clinico-histopathological correlational study.

AIM OF THE STUDY: The aim of this study was to correlate the clinical staging (clinical severity) with the histopathological staging (histopathological changes) of oral submucous fibrosis (OSF) patients, which would further assist the clinicians to formulate a definite treatment plan. MATERIALS AND METHODS: The study group consisted of 50 subjects who were clinically and histologically diagnosed as OSF. Detailed information was gathered in a pretested proforma with emphasis on the various addictions. The clinical findings were noted; punch biopsy was performed followed by histological examination. Clinical and histological staging were divided into four stages, as Stages I-IV according to Khanna and Andrade classification. RESULTS: The 50 subjects were in the age range of 18-70 years, of which 20 patients were in clinical Group III, 15 were in histopathological stage III, 2, 1, and 2 in Stage II, Stage I, and Stage IV, respectively, out of 5 patients in clinical Group IV, 4 were in histopathological staging IV and 1 was in Stage III, out of 5 patients in clinical Group I, 3 and 2 were in histologic Stages II and I, respectively. Statistical analysis with Chi-square test showed high significance with P < 0.001. CONCLUSION: The correlation of clinical and histopathological staging was found to be highly significant, thus suggesting that the subject with clinically advanced OSF had extensive fibrosis histologically.

Extensive Myiasis infestation associated with Oral Squamous Cell Carcinoma: Report of two cases.

Myiasis is the condition of infestation of the body by fly larvae (maggots). The deposited eggs develop into larvae, which penetrate deep structures causing adjacent tissue destruction. It is an uncommon clinical condition, being more frequent in tropical countries and hot climate regions, and associated with poor hygiene, suppurative oral lesions, alcoholism and senility. The diagnosis of Myiasis is basically made by the presence of larvae. The reported cases of oral Myiasis associated with oral cancer in the literature are few. This paper reports two cases of oral and maxillofacial Myiasis involving larvae in patients with squamous cell carcinoma in adult males. The condition was managed by manual removal of the larvae, one by one, with the help of forceps and subsequent management through proper health care.

Evaluation of the effect of water on three different light cured composite restorative materials stored in water: an in vitro study.

Objectives. The objective of this in vitro study was to investigate whether weight gain or loss in the three different composites occurs due to water absorption when they are stored in water. Methods. The composite restorative materials selected for this study included a microfine hybrid (Synergy) and two nanofilled composite restorative materials (Ceram X and Filtek Supreme Ultra). Twenty specimens of each material were fabricated of each composite material. Group A: Filtek Supreme Ultra, Group B: Synergy, Group C: Ceram X. Then all the specimens were stored in 10 ml Distilled water containing test tubes and placed in incubator at 37°C for six weeks. The weight changes of these specimens were measured daily for the first week and later once a week for next five weeks by using an electrical analytical balance. Results. The data was analyzed by one-way analysis of variance and Student's t test. All groups showed maximum amount of water absorption in the first week than gradual decrease in the water absorption from the second to the sixth week, as compared to the first week and there is no statistically significant difference between the groups tested. Conclusion. All the composite restorative material absorbs some amount of water. The water absorption of the composite may decrease the physical and mechanical properties of the composites; hence it is necessary to consider the type of the material before starting the treatment.