[Puncture of the posterior vault in the cytological diagnosis of malignant ovarian tumors]. / Opyt izucheniia punktatov zadnego svoda v tsitologicheskoi diagnostike zlokachestvennykh opukholei iaichnikov.

To confirm diagnosis, 4,614 punctures of the Douglas pouch through the posterior vault of the vagina have been performed in cases of suspected tumor located in the small pelvis since 1969. Further cytological examination established ovarian cancer in 871 cases, reactive changes in the mesothelium--186 and inflammatory lesions in the small pelvis--in 486 cases. Cytological data and the results of histological examination of resected tumors were compared: diagnosis was false-negative in 5.9% and false-positive--in 1.5% of cases. The said method was shown to be completely safe and highly instrumental both in cases of tumor in the small pelvis and detection of recurrences. Therefore, it may be recommended for application in out-patient service.

[Use of olivomycin in the treatment of cancer of the uterine cervix]. / Primenenie olivomitsina v lechenii raka sheiki matki

Olivomycin was used locally as 0.2% ointment (20-40 tampons) in 39 cervical cancer cases (I stage--27 patients, II--8, III--1 and IV--2 patients) and in 2 vaginal cancer cases (II stage). There was noted a visual disappearance of the neoplasm in 24 cases, the decrease up to 1/3 of initial tumor dimensions in 11 cases, up to 1/2-2/3--in 5 cases. There was no effect in one case of cervix adenocarcinoma. An extended extirpation of the uterus with its adnexa was carried out after the treatment in 36 cases, in 13 of which no histological signs of tumor were found. Two patients are being under observation, because they refused the operation in view of the complete disappearance of the tumor.

[Endolymphatic chemotherapy of cervix neoplasms]. / Ob endolimfaticheskoi khimioterapii raka sheiki matki

In the gynecological department of Rostov Oncological Institute endolymphatic polychemotherapy with a preliminary determination of tumor sensitivity to chemotherapy was employed in 54 patients with cervical cancer, 3 of them in stage III and IV having contraindications to radiotherapy. A combination of chemical substances and the dosage of single administration were as follows: thio-TEPA--100--150 mg + methotrexate 75--100 mg; thio-TEPA--100--150 mg + 5-fluoruracil--1000 mg; cyclophosphane--2000 mg + methotrexate--75--100 mg; cyclophosphane--1600 mg + methotrexate--75--100 mg + 5-fluoruracil--750 mg. Lymphoinfusion was made in the lower extremity, and after 7--10 days it was repeated in the second one. Visual disappearance of the tumor was noted in 17 patients, lessening of the tumor size by two-thirds--in 16, a 1/2 decrease--in 20. Among 23 patients in stage III after the treatment parametrial infiltrations disappeared entirely in 11 cases and only in pelvic walls--in 12. In 40 cases an extensive extirpation of the uterus with adnexa was performed. In all cases degenerative changes in tumor tissues were observed, whereas in 7 cases no tumor cells were found.