RESUMO
PURPOSE: An insertion/deletion (I/D) polymorphism of the gene for angiotensin-converting enzyme (ACE) is associated with higher ACE plasma levels and activity. This enzyme is known to play an important role in blood pressure regulation and the ACE I/D gene polymorphism has been suggested as a risk factor for atherosclerotic vascular diseases. The purpose of the present study was to investigate a hypothesized association between the ACE I/D polymorphism and retinal artery occlusion (RAO). METHODS: A total of 159 patients with RAO and 304 control subjects were enrolled in the present retrospective case-control study. ACE I/D genotypes were determined by polymerase chain reaction. RESULTS: Allelic frequencies and genotype distribution of the ACE I/D polymorphism did not significantly differ between patients and control subjects (ACE DD 25.8% versus 28.0%; p = 0.36). A logistic regression analysis predicted the presence of RAO by arterial hypertension and current smoking status, but not by ACE I/D genotypes. CONCLUSION: Our data suggest that the ACE I/D polymorphism is not a major risk factor for RAO.
Assuntos
Deleção de Genes , Mutagênese Insercional/genética , Peptidil Dipeptidase A/genética , Polimorfismo Genético , Oclusão da Artéria Retiniana/genética , Idoso , Estudos de Casos e Controles , DNA/genética , Feminino , Frequência do Gene , Genótipo , Humanos , Hipertensão/genética , Masculino , Reação em Cadeia da Polimerase , Oclusão da Artéria Retiniana/enzimologia , Estudos Retrospectivos , Fatores de Risco , Fumar/genéticaRESUMO
PURPOSE: To report a patient with intrusion of the encircling buckle late postoperatively after surgical treatment of a rhegmatogenous retinal detachment. DESIGN: Interventional case report. METHODS: We performed an encircling buckle procedure on a 77-year- old woman with a rhegmatogenous retinal detachment. Four years after the operation, the encircling buckle intruded into the vitreous cavity. RESULTS: After 3 months of diagnosis of the intrusion, the retina was detached totally. CONCLUSIONS: Intrusion of the encircling buckle without any additional segmental buckling element is a very rare late complication of retinal detachment surgery.
