RESUMO
Crataegus (hawthorn) has long been used as a folk medicine all around the world. Most of the studies with Crataegus species focus on effects on heart failure and cardiovascular disease. The pharmacological effects of Crataegus have been attributed mainly to the content of flavonoids, procyanidin, aromatic acid and cardiotonic amines. The present study investigated the blood pressure and the structure of the coronary arterial wall of L-NAME-induced hypertensive rats given an aqueous leaf extract of C. tanacetifolia (100 mg/kg), for 4 weeks via gavage. It was observed that C. tanacetifolia, especially the hyperoside fraction, prevented L-NAME-induced hypertension in rats and had beneficial effects on the cardiovascular system.
Assuntos
Pressão Sanguínea/efeitos dos fármacos , Vasos Coronários/efeitos dos fármacos , Hipertensão/prevenção & controle , Extratos Vegetais/uso terapêutico , Quercetina/análogos & derivados , Animais , Vasos Coronários/citologia , Crataegus/química , Inibidores Enzimáticos/toxicidade , Hipertensão/induzido quimicamente , Rim/enzimologia , Lipídeos/sangue , Masculino , Miocárdio/citologia , Miócitos de Músculo Liso/citologia , NG-Nitroarginina Metil Éster/toxicidade , Óxido Nítrico Sintase/análise , Óxido Nítrico Sintase/antagonistas & inibidores , Extratos Vegetais/farmacologia , Folhas de Planta/química , Quercetina/isolamento & purificação , Quercetina/farmacologia , RatosRESUMO
Five diterpenoids, three steroids, four triterpenoids and one flavonoid were isolated from the roots of Salvia amplexicaulis Lam. (Lamiaceae). Structures of these compounds were elucidated by spectroscopic analysis. The crude extract and the pure compounds were tested for cardiovascular parameters using Wistar Albino rats. The crude extract, and 7-oxo-abieta-9,12,14-triene, ferruginol, stigmast-4-en-3-one showed a vasodepressor effect.
Assuntos
Diterpenos/uso terapêutico , Fitoterapia , Preparações de Plantas/uso terapêutico , Salvia/química , Vasoconstritores/uso terapêutico , Animais , Pressão Sanguínea/efeitos dos fármacos , Diterpenos/química , Diterpenos/isolamento & purificação , Frequência Cardíaca/efeitos dos fármacos , Masculino , Estrutura Molecular , Raízes de Plantas/química , Ratos , Ratos Wistar , Vasoconstritores/química , Vasoconstritores/isolamento & purificaçãoRESUMO
From the roots of Salvia syriaca L., in addition to known terpenoids, a new rearranged diterpene, named salvisyrianone, was isolated. The structure of the new compound was assigned from spectral data. The crude extract and the single compounds were tested for cardiovascular parameters using Wistar Albino rats. Antihypertensive activity was established in the crude extract of the roots as well as in two compounds, ferruginol and 3 beta-hydroxystigmast-5-en-7-one.
Assuntos
Anti-Hipertensivos/isolamento & purificação , Diterpenos/isolamento & purificação , Terpenos/isolamento & purificação , Animais , Anti-Hipertensivos/química , Anti-Hipertensivos/farmacologia , Diterpenos/química , Diterpenos/farmacologia , Espectroscopia de Ressonância Magnética , Masculino , Espectrometria de Massas , Estrutura Molecular , Ratos , Ratos Wistar , Terpenos/química , Terpenos/farmacologiaRESUMO
Prangos platychlaena has been used in traditional medicine in eastern Turkey. It stops bleeding and heals the scars when applied externally. When the isolated coumarins were tested against bacterial strains, only a slight activity was obtained.
Assuntos
Anti-Infecciosos/farmacologia , Cumarínicos/farmacologia , Extratos Vegetais/farmacologia , Plantas Medicinais , Antibacterianos , Bacillus subtilis/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Fracionamento Químico , Clorofórmio/química , Cumarínicos/química , Cumarínicos/isolamento & purificação , Escherichia coli/efeitos dos fármacos , Klebsiella pneumoniae/efeitos dos fármacos , Medicina Tradicional , Testes de Sensibilidade Microbiana , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus epidermidis/efeitos dos fármacos , Relação Estrutura-Atividade , TurquiaRESUMO
A balloon-tipped catheter has recently become available which, when placed in the pulmonary artery, in addition to enabling the usual measurements of pulmonary arterial pressure, pulmonary capillary wedge pressure, and cardiac output by thermodilution, measures mixed venous oxygen saturation (SvO2) by spectrophotometry. Unlike the measurement of cardiac output by thermodilution, which is done intermittently, the continuous measurement of SvO2 is an effective method of monitoring hemodynamically unstable patients, since changes in cardiac output will immediately become apparent via a corresponding change in SvO2. This is of particular benefit in patients in whom knowledge of the immediate effects of therapy is important. It is also of value in assessing the time of onset of action and duration of action when a cardioactive drug is given to increase cardiac output. We suggest that monitoring SvO2 will provide an earlier indication of the effect of both diagnostic and therapeutic interventions and, therefore, will improve our management in such patients.
