RESUMO
BACKGROUND: Endemicity of filariasis in tropical countries calls for its high incidence. However, the disease is often overlooked or misdiagnosed because unusual presentations. As a result the patients are often subjected to numerous investigations before a definitive diagnosis is made. CASES: Microflaria ofWucheria bancrofti was observed in fine needle aspiration (FNA) smears of 5 cases including 1 axilla?ry lump, 1 epididymal nodule, 1 spermatic cord nodule and 2 thyroid nodules. All 5 cases presented with clinical details not diagnostic of filariasis. CONCLUSION: The importance of detecting microfilaria in unsuspected cases cannot be undermined and has been highlighted in this report. Careful screening of FNA smears might be helpful in detecting microfilaria even in patients not presenting with features characteristic of the disease. It will prevent delay in institution of specific therapy and subsequent morbidity of the patient.
Assuntos
Filariose/parasitologia , Doenças dos Genitais Masculinos/parasitologia , Doenças Linfáticas/parasitologia , Nódulo da Glândula Tireoide/parasitologia , Wuchereria bancrofti/isolamento & purificação , Adulto , Animais , Axila , Biópsia por Agulha Fina , Feminino , Doenças dos Genitais Masculinos/patologia , Humanos , Doenças Linfáticas/patologia , Masculino , Pessoa de Meia-Idade , Nódulo da Glândula Tireoide/patologiaRESUMO
Hemoglobin E (beta26Glu --> Lys) is the most common hemoglobin (Hb) variant in Southeast Asia and the second most prevalent worldwide. However in India, it is prevalent in Bengal and the north-eastern region, but relatively rare in the rest of the country. Identification of this Hb variant is important, because the doubly heterozygous state for HbE and beta-thalassemia is characterized clinically by thalassemia major, a situation different from other compound heterozygous states for structural beta-chain variants and beta-thalassemia. Thus, the affected individual may be symptomatic and transfusion dependent at an early age. This paper reports four cases with Hb E trait, three cases with hemoglobin E disease and another four cases with Ebeta-thalassemia. Laboratory investigations are based on RBC indices and high performance liquid chromatography (HPLC). A negative correlation has been found to exist between levels of HbA(2) and RBC indices including the MCV and MCH. A similar correlation has been seen between levels of HbF with Hb, RBC count, and MCV. The main aim is to increase the awareness of this relatively rare disorder, so that it can be included in the differential diagnosis of patients presenting clinically like thalassemia intermedia or thalassemia major. This awareness may also help in prenatal diagnosis, genetic counseling and clinical management. The clinical, hematological and laboratory features of this disorder are also discussed.
Assuntos
Hemoglobina E/genética , Hemoglobinúria/epidemiologia , Índices de Eritrócitos , Hemoglobina Fetal/análise , Genótipo , Globinas/genética , Hemoglobina A2/análise , Hemoglobina E/análise , Hemoglobinúria/sangue , Hemoglobinúria/complicações , Hemoglobinúria/genética , Humanos , Índia/epidemiologia , Prevalência , Talassemia beta/sangue , Talassemia beta/complicações , Talassemia beta/epidemiologia , Talassemia beta/genéticaRESUMO
A 42 year old male presented with painless soft tissue mass 8x7x6.5 cm in right scapular region for 2 months. Fine needle aspiration cytology (FNAC) showed a malignant clear cell tumour. Ultrasonography (USG) abdomen revealed a heterogeneous mass m 8.6x7x8.4 at the lower pole of left kidney. USG guided FNAC from left kidney mass showed cytomorphology consistent with RCC.
