RESUMO
A familial lympho-epithelial thymoma with constitutional chromosomal translocation t (14;20) (q24;p13) is presented: the thymoma and its particular translocation are present in the mother and the two sons of her offspring. The small number of cases do not allow establishing any relation between thymoma and this particular translocation. Concerning genetic counseling, an annual thoracic radiography is necessary for all the other family members, carriers or not of the translocation.
Assuntos
Aberrações Cromossômicas/genética , Cromossomos Humanos Par 14/ultraestrutura , Cromossomos Humanos Par 20/ultraestrutura , Timoma/genética , Neoplasias do Timo/genética , Translocação Genética , Adulto , Transtornos Cromossômicos , Feminino , Aconselhamento Genético , Humanos , Masculino , Pessoa de Meia-Idade , Linhagem , Radiografia , Timoma/diagnóstico por imagem , Neoplasias do Timo/diagnóstico por imagemRESUMO
The cytogenetic analysis of 67 meningiomas (58 intracranial and 9 spinal tumors) identified chromosomal abnormalities in 63% of cases. When chromosomes involved in numerical and structural changes with a frequency of more than one standard deviation above the mean were considered, distinct cytogenetic patterns could be identified according to sex, anatomical location and histology. The chromosomes more frequently affected were 1, 2, 3, 4, 8, 14, 15, 19, 22, Y. No conclusion could be drawn regarding the prognostic significance of these karyotypic alterations.
