An Ensemble of CNN Models for Parkinson's Disease Detection Using DaTscan Images.

Parkinson's Disease (PD) is a progressive central nervous system disorder that is caused due to the neural degeneration mainly in the substantia nigra in the brain. It is responsible for the decline of various motor functions due to the loss of dopamine-producing neurons. Tremors in hands is usually the initial symptom, followed by rigidity, bradykinesia, postural instability, and impaired balance. Proper diagnosis and preventive treatment can help patients improve their quality of life. We have proposed an ensemble of Deep Learning (DL) models to predict Parkinson's using DaTscan images. Initially, we have used four DL models, namely, VGG16, ResNet50, Inception-V3, and Xception, to classify Parkinson's disease. In the next stage, we have applied a Fuzzy Fusion logic-based ensemble approach to enhance the overall result of the classification model. The proposed model is assessed on a publicly available database provided by the Parkinson's Progression Markers Initiative (PPMI). The achieved recognition accuracy, Precision, Sensitivity, Specificity, F1-score from the proposed model are 98.45%, 98.84%, 98.84%, 97.67%, and 98.84%, respectively which are higher than the individual model. We have also developed a Graphical User Interface (GUI)-based software tool for public use that instantly detects all classes using Magnetic Resonance Imaging (MRI) with reasonable accuracy. The proposed method offers better performance compared to other state-of-the-art methods in detecting PD. The developed GUI-based software tool can play a significant role in detecting the disease in real-time.

Breast cancer detection from thermal images using a Grunwald-Letnikov-aided Dragonfly algorithm-based deep feature selection method.

Breast cancer is one of the deadliest diseases in women and its incidence is growing at an alarming rate. However, early detection of this disease can be life-saving. The rapid development of deep learning techniques has generated a great deal of interest in the medical imaging field. Researchers around the world are working on developing breast cancer detection methods using medical imaging. In the present work, we have proposed a two-stage model for breast cancer detection using thermographic images. Firstly, features are extracted from images using a deep learning model, called VGG16. To select the optimal subset of features, we use a meta-heuristic algorithm called the Dragonfly Algorithm (DA) in the second step. To improve the performance of the DA, a memory-based version of DA is proposed using the Grunwald-Letnikov (GL) method. The proposed two-stage framework has been evaluated on a publicly available standard dataset called DMR-IR. The proposed model efficiently filters out non-essential features and had 100% diagnostic accuracy on the standard dataset, with 82% fewer features compared to the VGG16 model.

Can R&D investment reduce the impact of COVID-19 on firm performance?-Evidence from India.

This study examines whether investing in R&D reduces the impact of exogenous shocks like the COVID-19 on stock market performance and accounting performance of manufacturing firms in India. For the sample of listed manufacturing firms, the paper finds that the firms engaged in R&D activities had lower negative cumulative abnormal return than those firms that did not invest in R&D in the pre-pandemic period using multiple event windows. The result suggests that R&D investments can lower value erosion for the shareholders during a severe crisis period. Further, using a difference-in-difference fixed effects model, the study finds that manufacturing firms engaged in R&D activities in the pre-pandemic period exhibited higher return on sales and growth of total income during the pandemic quarter vis-à-vis the non-R&D firms. The favorable accounting performance indicates the possibility of firm-level R&D being associated with the firm's ability to adjust its functioning during a crisis, thereby reducing the effect of the crisis. Finally, the study documents that government intervention to reduce the spread of the virus had a differential impact on firms based on their industry of operation. The findings have implications for investors, corporate managers, and policymakers in India.