A longitudinal study of thyroid autoantibodies in pregnancy: the importance of test timing.

OBJECTIVE: Thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TGAb) are frequently measured to investigate thyroid dysfunction in pregnancy. Despite the recognized fall of these autoantibodies in pregnancy, there is limited guidance on the timing of such testing. We assessed optimal test timing of TPOAb/TGAb for the detection of Hashimoto's thyroiditis and post-partum thyroid dysfunction (PPTD). DESIGN: Prospective longitudinal study with recruitment in Trimester 1. PATIENTS: Healthy women ≤13 weeks' gestation from Mercy Hospital for Women, a tertiary obstetric hospital in Melbourne. MEASUREMENTS: Serum TPOAb, TGAb, TSH and fT4 were measured at Trimester 1 (T1), Trimester 2(T2), Trimester 3(T3) and postpartum (PP) in each participant. Post-partum thyroid dysfunction (PPTD) was defined if TSH deviated from the assay's nonpregnant reference interval. Longitudinal random-effect logistic regression was used to investigate the association between time and positive/negative thyroid autoantibody status. RESULTS: Samples from 140 women at T1 (12·0: 10·3-13·0) (median: IQR weeks' gestation); 95 at T2 (24·3: 23·0-25·9), 79 at T3 (35·9: 34·8-36·7) and 83 at PP (12·4: 10·8-14·6 weeks post-partum) were attained. At T1, 13 (9%) and 15 (11%) women had positive TPOAb and TGAb, respectively. The odds of having a positive TPOAb were 96% lower at T2 [OR = 0·04 (95% CI: 0·02-0·8; P = 0·03)] and 97% lower at T3 [OR = 0·03 (95% CI: 0·001-0·6; P = 0·02)] than at T1. Similarly, the odds of having a positive TGAb were 99·4% lower [OR = 0·006 (95% CI: 0-0·3; P = 0·01)] at T2, and 99·5% lower [OR = 0·005 (95% CI: 0-0·4; P = 0·02)] at T3 than at T1. The ROC analysis diagnostic ORs for a positive TPOAb and/or TGAb to predict PPTD were 7·8 (95% CI: 2·2-27·6), 1·2 (95% CI: 0-8·9), 2·0 (95% CI: 0-16·8), and 12·2 (95% CI: 3·3-44·9) at T1, T2, T3 and post-partum, respectively. CONCLUSIONS: A significant proportion of pregnant women lose their thyroid autoantibody positivity after T1. The gestation-dependent loss of TPOAb/TGAb positivity and reduction in diagnostic accuracy for predicting PPTD limits the value of testing at T2 and T3.

[Volvulus of the mobile spleen. Conservative laparoscopic treatment]. / Volvulus de la rate mobile. Traitement conservateur coelioscopique.

BACKGROUND: Volvulus of the mobile spleen is a rare condition generally manifested by acute sudden onset abdominal pain localized in the left flank. Ultrasound or computed tomographic imaging generally provides the diagnosis. CASE REPORT: An 18-year-old patient was hospitalized for acute pain of the left flank that had begun 48 hours earlier. The abdominal scan visualized a volvulus of a mobile spleen. Laparoscopic distortion was successful, allowing normal recoloration of the spleen. DISCUSSION: Rapid intervention is crucial for conservative treatment. Laparoscopic treatment allows distortion manoeuvres and splenopexia using a mesh. This is the first reported case of successful conservative laparoscopic treatment of volvulus of a mobile spleen.

[Cystic dystrophy of an aberrant pancreas. Surgery after failure of medical therapy]. / Dystrophie kystique sur pancréas aberrant. Chirurgie après échec d'un traitement médical.

BACKGROUND: Cystic dystrophy of aberrant pancreas, characterized by cystic formations in ectopic pancreatic tissue, produces variable signs. Treatment is difficult. CASE REPORT: Our patient presented signs of acute pancreatitis and angiocholitis due to cystic dystrophy of an aberrant pancreas situated in the duodenal wall associated with chronic alcoholic pancreatitis. Prolonged medical treatment was unsuccessful. Duodenopancreatectomy with preservation of the tail led to complete regression of the clinical signs. DISCUSSION: Signs of cystic dystrophy of an aberrant pancreas vary greatly. Diagnosis is generally established on the basis of echoendoscopic findings. After failure of medical treatment, duodenopancreatectomy with preservation of the tail could be the most appropriate surgical treatment, hypothesizing that the disorders result from obstruction of the Wirsung and the lower main bile ducts.