RESUMO
A sugar poly(orthoester)-based drug delivery system was constructed to achieve acidity-enhanced drug delivery and cell killing.
Assuntos
Carboidratos/química , Portadores de Fármacos/química , Interações Hidrofóbicas e Hidrofílicas , Nanoestruturas/química , Poliésteres/química , Morte Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Doxorrubicina/química , Doxorrubicina/farmacologia , Células HEK293 , Humanos , Concentração de Íons de HidrogênioRESUMO
High molecular weight sugar poly(orthoesters) were synthesized through reverse anomeric effect (RAE). We demonstrated that when RAE-enabled promoters, such as 4-(dimethylamino)pyridine (DMAP), triphenylphosphine (TPP) or imidazole, were employed, efficient polymerizations were achieved, giving sugar poly(orthoesters) with molecular weights up to 18 kDa.
Assuntos
Carboidratos/química , Poliésteres/química , Poliésteres/síntese química , Técnicas de Química Sintética , EstereoisomerismoRESUMO
The synthesis of clickable polysaccharides was achieved by using alkynylated 1,6-anhydro glucopyranose as a monomer and BF3·OEt2 as an effective catalyst. Subsequent click conjugation with polyethylene glycol (PEG) afforded PEG-grafted polysaccharides in nearly quantitative efficiency.
