RESUMO
Toxicologic characteristics of anti-tumor medication lisomustine. The authors presented materials on experimental studies of toxicity and jeopardy to justify hygienic regulation of workplace air for antitumor medication lisomustine: data on acute toxicity, results of irritative, resorptive and sensitizing effects evaluation, mutagenous and cumulative effects, influence on reproduction.
Assuntos
Antineoplásicos/toxicidade , Indústria Farmacêutica , Compostos de Nitrosoureia/toxicidade , Saúde Ocupacional , Local de Trabalho , Ar , Experimentação Animal , Animais , Antineoplásicos/administração & dosagem , Interpretação Estatística de Dados , Feminino , Dose Letal Mediana , Masculino , Camundongos , Testes de Mutagenicidade , Compostos de Nitrosoureia/administração & dosagem , Ratos , Reprodução/efeitos dos fármacos , Estatísticas não Paramétricas , Fatores de TempoRESUMO
The authors present materials on experimental basis of approximate safe level of exposure to new anti-flu medication Triazavirin in air of workplace. The article covers acute toxicity parameters for various intake routes, results of irritating and sensitizing effects evaluation, determination of threshold concentration for single inhalation effect, value of recommended approximate safe level of exposure.
