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Mov Disord ; 28(4): 529-33, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23239509

RESUMO

BACKGROUND: Pancreatic polypeptide is released immediately after food ingestion. The release is operated by vagal-abdominal projections and has therefore been suggested as a test for vagal nerve integrity. Pathoanatomical and clinical studies indicate vagal dysfunction in early Parkinson's disease (PD). METHODS: We assessed the postprandial secretion of pancreatic polypeptide and motilin in healthy controls (n = 18) and patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD, n = 10), a potential premotor stage of PD, as well as in drug-naive (n = 19) and treated (n = 19) PD patients. RESULTS: The postprandial pancreatic polypeptide secretion showed a physiological pattern in all groups and even an enhanced response in drug-naive PD and iRBD. Motilin concentrations correlated with pancreatic polypeptide concentrations. CONCLUSIONS: Postprandial pancreatic polypeptide secretion is not a suitable test for vagal nerve integrity in PD. The unimpaired pancreatic polypeptide response in iRBD and PD might be explained by partially intact vagal-abdominal projections or compensatory mechanisms substituting a defective neuronal brain-gut axis.


Assuntos
Polipeptídeo Pancreático/biossíntese , Doença de Parkinson/metabolismo , Transtorno do Comportamento do Sono REM/metabolismo , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Motilina/biossíntese , Doença de Parkinson/fisiopatologia , Período Pós-Prandial/fisiologia , Transtorno do Comportamento do Sono REM/fisiopatologia
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