Assuntos
Antipsicóticos , Esquizofrenia/mortalidade , Adulto , Antipsicóticos/efeitos adversos , Antipsicóticos/economia , Antipsicóticos/uso terapêutico , Aripiprazol , Comorbidade , Custos de Medicamentos/estatística & dados numéricos , Tratamento Farmacológico/economia , Tratamento Farmacológico/mortalidade , Tratamento Farmacológico/estatística & dados numéricos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Humanos , Seguro por Deficiência/economia , Seguro por Deficiência/estatística & dados numéricos , Pessoa de Meia-Idade , Piperazinas/efeitos adversos , Piperazinas/economia , Piperazinas/uso terapêutico , Quinolonas/efeitos adversos , Quinolonas/economia , Quinolonas/uso terapêutico , Esquizofrenia/tratamento farmacológico , Esquizofrenia/economia , Licença Médica/estatística & dados numéricos , SuéciaRESUMO
BACKGROUND: Drug costs are increasing despite the introduction of cheaper generic drugs. The aim of the present study was to analyse the entire costs of hospital care, out-patient care, and the cost of drugs for 16 months following a myocardial infarction (MI) to see to what extent drug costs contribute to the overall costs of care. METHODS: Diagnoses and costs for care as well as mortality data obtained from the Västra Götaland Region, Sweden, and drug costs from the Swedish Board of Health and Welfare, were merged in a computer file. Patients registered from 1 July 2005 to 30 June 2006 were followed from 28 days after an MI, with follow-up until 31 October 2006. RESULTS: Of 4,725 patients, 711 died before the start of the study and 721 during follow-up. Higher age [hazard ratio (HR, 95%CI) = 1.06 (1.05-1.07)], previous MI [HR = 1.31 (1.13-1.53)] and diabetes mellitus [HR = 1.34 (1.13-1.58)] were associated with increased mortality, which decreased with coronary interventions: CABG/PCI [HR = 0.19 (0.14-0.27)]. In a multivariable analysis, mortality was lower for patients taking simvastatin [HR = 0.62 (0.50-0.76)] and clopidogrel [HR = 0.58 (0.46-0.74)]. CONCLUSION: Costs for out-patient care accounted for 25% and drugs for 5% of total costs. If patients not treated with simvastatin or clopidogrel had received these drugs, an additional 154-306 lives might have been saved. Drug costs would be higher, but total costs lower. Thus, even expensive drugs may reduce overall costs.
Assuntos
Anticolesterolemiantes/uso terapêutico , Custos de Cuidados de Saúde , Infarto do Miocárdio/tratamento farmacológico , Infarto do Miocárdio/mortalidade , Inibidores da Agregação Plaquetária/uso terapêutico , Sinvastatina/uso terapêutico , Ticlopidina/análogos & derivados , Antagonistas Adrenérgicos beta/economia , Antagonistas Adrenérgicos beta/uso terapêutico , Adulto , Fatores Etários , Idoso , Inibidores da Enzima Conversora de Angiotensina/economia , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Anticolesterolemiantes/economia , Aterectomia/economia , Ablação por Cateter/economia , Clopidogrel , Ponte de Artéria Coronária/economia , Diabetes Mellitus/mortalidade , Quimioterapia Combinada/economia , Feminino , Custos de Cuidados de Saúde/estatística & dados numéricos , Custos Hospitalares , Humanos , Masculino , Registro Médico Coordenado , Pessoa de Meia-Idade , Infarto do Miocárdio/economia , Infarto do Miocárdio/terapia , Inibidores da Agregação Plaquetária/economia , Prognóstico , Modelos de Riscos Proporcionais , Sistema de Registros , Fatores de Risco , Sinvastatina/economia , Suécia/epidemiologia , Ticlopidina/economia , Ticlopidina/uso terapêutico , Resultado do TratamentoRESUMO
PURPOSE: Aspirin is effective in secondary prevention of cardiovascular disease. The results are less convincing when aspirin is used for primary prevention even in high-risk patients (i.e., patients with diabetes). We therefore analyzed the effect of aspirin on mortality and serious bleeding in diabetic patients with and without cardiovascular disease. METHODS: We performed a record linkage study of the patient registry of the Västra Götaland region in south-western Sweden, the Swedish mortality register and the Swedish register of dispensed drugs. All diabetic patients (n = 58 465) from 1 July 2005 to 30 June 2006 were followed up with respect to bleeding until 31 October 2006, and mortality until 31 December 2006. RESULTS: When 19 confounding factors (diseases and interventions) were assessed, aspirin significantly increased mortality in diabetic patients without cardiovascular disease from 17% (95% confidence interval; 95%CI, 1-36) at age 50 years to 29% (16-43) at age 85 years. In contrast aspirin tended to decrease mortality among elderly diabetic patients with cardiovascular disease. Theoretical calculations indicated that aspirin caused 107 excess deaths among diabetic patients without cardiovascular disease and prevented 164 deaths among diabetic patients with cardiovascular disease. Aspirin also increased the risk of serious bleeding by 46% (95%CI, 22-75) in diabetic patients without cardiovascular disease but decreased the risk among those with cardiovascular disease. CONCLUSION: Aspirin use in diabetes patients without cardiovascular disease remains controversial and current guidelines should be revised until results from ongoing large randomized controlled trials become available.