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BMJ Case Rep ; 17(1)2024 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-38238162

RESUMO

Shiga toxin (Stx)-producing Escherichia coli-mediated haemolytic uraemic syndrome is a primary thrombotic microangiopathy, typified by the development of microangiopathic haemolytic anaemia, thrombocytopaenia and acute renal failure. It is a leading cause of acute renal failure in paediatrics, with a second peak in prevalence in adults over the age of 60. Presentations of Stx-producing E. coli-mediated haemolytic uraemic syndrome in young adults are rare. We present the case of a previously well female in her early 30s presenting with Stx-producing E. coli-mediated haemolytic uraemic syndrome with severe renal and neurological manifestations. Eculizumab was administered due to the severity of presentation and disease trajectory refractory to initial supportive therapy. A significant clinical and biochemical improvement was observed following eculizumab.


Assuntos
Injúria Renal Aguda , Anticorpos Monoclonais Humanizados , Infecções por Escherichia coli , Síndrome Hemolítico-Urêmica , Escherichia coli Shiga Toxigênica , Humanos , Criança , Feminino , Toxina Shiga/uso terapêutico , Síndrome Hemolítico-Urêmica/tratamento farmacológico , Infecções por Escherichia coli/complicações , Infecções por Escherichia coli/tratamento farmacológico , Injúria Renal Aguda/tratamento farmacológico , Injúria Renal Aguda/etiologia
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