Anaphylaxis due to the excipient polysorbate 80

No disponible

In vivo diagnostic tests in adverse reactions to quinolones.

BACKGROUND AND OBJECTIVE: Contradictory reports of the sensitivity of skin tests in quinolone allergy have been reported. Our objectives were to describe the outcome of quinolone skin and challenge tests in patients consulting because of a history of adverse reaction to quinolone and to compare the outcome of quinolone skin tests and challenge tests in the subsample of patients who had undergone both tests. METHODS: We reviewed skin and challenge test results of all patients who consulted at our allergy service over the last 5 years because of a history of quinolone adverse reaction in the form of urticaria or anaphylaxis within 1 hour of drug intake (group 1), urticaria or maculopapular eruption between 1 and 24 hours after intake (group 2) or after 24 hours had passed (group 3), or atypical symptoms (group 4). RESULTS: A total of 71 cases were identified: 27, 8, 24 and 12 in groups 1 through 4, respectively. Skin tests were performed in all patients, with positive results in 31 patients. In group 1, 62.9 % of these patients showed positive skin tests and 22.2% showed positive challenge tests, whereas in the other 3 groups, about 30% of patients had positive skin tests and a variable percentage (from 0% to 4.1% depending on the group) had positive challenge tests. Quinolone challenge tests were performed in 10 patients with positive skin tests (5 of them with positive results) and in 34 patients with negative skin tests (2 of them with positive results). CONCLUSIONS: A highly suggestive history of quinolone allergy is more frequently associated with positive skin tests and positive challenge tests. Therefore, skin tests help to predict the result of the challenge test.

Anaphylaxis produced by oxaliplatin.

We are discussing two patients, with clinically compatible reactions, who display an immediate hypersensitive mechanism following the administration of oxaliplatin, confirmed by the performance of cutaneous tests.

[Allergy to Anisakis simplex. Report of 2 cases and review of the literature]. / Alergia a Anisakis simplex. Comunicación de tres casos y revisión de la literatura.

Anisakis simplex is a nematode which parasitizes mainly fish and cephalopods and accidentally human beings after ingestion. Apart from the different digestive syndromes, this organism has recently been involved as cause of IgE-mediated allergic reactions of variable degree (urticaria to severe angioedema). In this report three patients with the diagnosis of allergy to Anisakis simplex are reported and a review of the literature is made.

[Erythroderma caused by carbamazepine. Diagnosis with skin patch]. / Eritrodermia por carbamacepina. Su diagnóstico mediante parche cutáneo.

We present two cases of cutaneous erythroderma induced by carbamazepine therapy, both cases with just cutaneous affection and only one suspicious drug. A cutaneous patch study, with standard battery from the Spanish Contact Dermatitis Research Group, vaseline with carbamazepine at 10% and lectures at 48 and 96 hours, was conducted. The result was positive for carbamazepine and negative for all other patches in both cases. All controls were negative. This is a very simple test, easy to perform, specific and with low side effects, allowing the diagnosis of this pathology.

Asma bronquial / Bronchial asthma

La obstruccion reversible de las vias aereas como consecuencia de estimulos diversos exige tratamiento inmediato y un profundo y concienzudo estudio de su etiologia, patogenia y factores agravantes, para poder conducir adecuadamente una terapia que mejore el pronostico a largo plazo y la calidad de vida del paciente

Urticaria y angioedema / Urticaria and angioedema

Urticaria y angioedema son un problema clinico muy frecuente, cuyos mecanismos patogenicos pueden ser o no inmunologicos y precisan de un diagnostico cuidadoso para identificar las causas desencadenantes.