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1.
Clin. transl. oncol. (Print) ; 10(4): 227-230, abr. 2008. ilus
Artigo em Inglês | IBECS | ID: ibc-123438

RESUMO

Expression of blood group antigens in normal, displastic and tumoral uterine cervix from 35 hysterectomised women with carcinoma of the cervix was investigated; the results were correlated with patients' ABH phenotype and secretor status. We used an indirect immunoperoxidase technique and a panel of monoclonal antibodies and lectins directed against different antigenic specificities. Anomalous expression of blood group antigens in premalignant lesions from cervix was found. Partial loos of expression of blood group antigens and some lectins in different grades of cervical intraepithelial neoplasia, and a total loss of expression in CIN III and in infiltrating carcinoma of the cervix from secretor patients was revealed. The findings herein described confirm the importance of these antigens as tumour markers and they might be useful for the study of cervical carcinogenesis (AU)


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Assuntos
Humanos , Feminino , Antígenos de Grupos Sanguíneos/biossíntese , Biomarcadores Tumorais/análise , Neoplasias do Colo do Útero/metabolismo , Neoplasias do Colo do Útero/patologia , Lesões Pré-Cancerosas/metabolismo , Lesões Pré-Cancerosas/patologia , Colo do Útero/patologia
2.
Arch Esp Urol ; 50(8): 831-6, 1997 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-9463280

RESUMO

OBJECTIVE: Low grade, low stage superficial bladder tumors have, in general, a good prognosis; however, some of these tumors progress and behave more aggressively, displaying a high incidence of recurrence and rapid transformation into a higher grade of malignancy with deep invasion of the bladder wall. Numerous studies have been conducted on markers which help to predict this transformation. METHODS: The expression of the anti-proliferating cell nuclear antigen (PCNA) was examined in bladder specimens from 72 patients with superficial transitional cell carcinoma utilizing the PC10 monoclonal antibody. We have compared expression of PCNA with other markers. The cases were divided into three groups: group A comprised patients with good clinical behaviour; group B comprised patients who developed recurrences of the same histological grade and group C comprised patients with superficial TCC who developed muscle wall invasion within 2 years. RESULTS/CONCLUSIONS: Our results demonstrate that the monoclonal antibody PC10 is an excellent marker for the aggressive, low stage and low grade superficial bladder tumours and can distinguish these from those which have a good clinical behaviour.


Assuntos
Biomarcadores Tumorais , Carcinoma de Células de Transição/patologia , Antígeno Nuclear de Célula em Proliferação , Neoplasias da Bexiga Urinária/patologia , Anticorpos Monoclonais , Biópsia , Humanos , Técnicas Imunoenzimáticas , Estadiamento de Neoplasias , Prognóstico , Bexiga Urinária/patologia
3.
Invest Clin ; 38(4): 227-59, 1997 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-9527390

RESUMO

The results of examining in the course of the past twenty years a considerable number of malignant tumors with transmission electron microscopy and immunohistochemistry are discussed. The neoplasms were divided into epithelial tumors, tumors of fusiform cells, malignant round cell tumors and tumors of endocrine nature. The main ultrastructural findings and the results of immunohistochemical studies were pointed out regarding their contributory role in the diagnosis as well as for the prognosis and treatment of patients with cancer.


Assuntos
Imuno-Histoquímica , Microscopia Eletrônica , Neoplasias/diagnóstico , Biomarcadores Tumorais/análise , Diagnóstico Diferencial , Estudos de Avaliação como Assunto , Humanos , Neoplasias/química , Neoplasias/classificação , Neoplasias/ultraestrutura , Estudos Retrospectivos
4.
Eur J Cancer ; 32A(3): 444-6, 1996 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-8814689

RESUMO

The expression of the anti-proliferating cell nuclear antigen (PCNA) was examined in bladder specimens from 48 patients with superficial transitional carcinoma, with the use of the PC10 monoclonal antibody. In vesical tumours with good clinical behaviour, we found a median PCNA positivity of 7.1% with a range of 5-25%. In vesical tumours with high incidence of recurrence, the median was 36.6% with a range of 15-80%. In vesical tumours with a strong tendency to invasion, the median positivity for PCNA staining was 68% with a range of 40-92%. In conclusion, we believe that using PC10 immunostaining to determine a nuclear proliferative fraction is a quick and simple method of studying the prognosis of patients who have vesical tumours of low grade and low stage.


Assuntos
Carcinoma de Células de Transição/química , Proteínas de Neoplasias/análise , Antígeno Nuclear de Célula em Proliferação/análise , Neoplasias da Bexiga Urinária/química , Humanos , Imuno-Histoquímica , Prognóstico
5.
Anticancer Res ; 16(2): 963-7, 1996.
Artigo em Inglês | MEDLINE | ID: mdl-8687160

RESUMO

Although some types of intestinal metaplasia are considered to be potentially pre-malignant lesions leading to gastric carcinoma, their high frequency and variability limit their usefulness as early markers of malignant progression. The present study was carried out to search for parameters which could be used in conjunction with histological diagnosis to identify groups of patients with a high risk for developing gastric neoplasia. The expression of proliferating cell nuclear antigen (PCNA), as revealed by immunohistochemical staining of anti-PCNA monoclonal antibody (PC10) in 82 endoscopic biopsy specimens, was compared with the histological classification of intestinal metaplasia, the biochemical composition of gastric mucins and the expression of blood group Lewis antigens. Statistically significant (p 0.001) correlation between the PCNA labelling index (the percentage of positive cells in more than 700 tumor cells per sample) and the histological type of intestinal metaplasia, the presence of sulphomucins, and the presence of anomalous Lewis a antigen was found. We conclude that a high PCNA-labelling index in the gastric mucosa, with a histological diagnosis of incomplete intestinal metaplasia, could constitute a good prognostic marker of the severity of the histologic lesion. These parameters, together with others such as the presence of sulphomucins and of cells expressing anomalous Lewis a antigen, may be used to define patients with a high risk of developing a gastric neoplasia.


Assuntos
Intestinos/química , Proteínas de Neoplasias/análise , Lesões Pré-Cancerosas/química , Antígeno Nuclear de Célula em Proliferação/análise , Núcleo Celular/química , Humanos , Intestinos/patologia , Antígenos do Grupo Sanguíneo de Lewis , Metaplasia/sangue , Lesões Pré-Cancerosas/sangue , Lesões Pré-Cancerosas/patologia , Prognóstico , Neoplasias Gástricas/sangue , Neoplasias Gástricas/química , Neoplasias Gástricas/patologia
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