1.
J Clin Neurosci
; 18(11): 1554-5, 2011 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21868233
RESUMO
We report a now 74-year-old patient who was successfully treated with a methotrexate (MTX)-ssbased polychemotherapy protocol (Bonn protocol) for primary central nervous system lymphoma (PCNSL) in 1996. When presenting with an unusually late relapse after 13 years of tumor-free survival the diagnosis was made on the basis of clinical and radiological criteria. In the context of the very limited treatment options for recurrent PCNSL, it is reassuring that the re-application of high dose-MTX-based polychemotherapy, including intraventricular treatment, again succeeded in a sustained complete response with still low neurotoxicity.
Assuntos
Antimetabólitos Antineoplásicos/uso terapêutico , Neoplasias do Sistema Nervoso Central/tratamento farmacológico , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Metotrexato/uso terapêutico , Idoso , Neoplasias do Sistema Nervoso Central/patologia , Humanos , Linfoma Difuso de Grandes Células B/patologia , Pessoa de Meia-Idade , Recidiva , Indução de Remissão
2.
J Neurooncol
; 101(2): 343-4, 2011 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20532953
4.
J Chromatogr
; 28(2): 385-90, 1967 Jun.
Artigo
em Alemão
| MEDLINE
| ID: mdl-4293250