RESUMO
BACKGROUND: Primary lymphoedema (LE) is the consequence of lymphatic insufficiency, usually associated with hypoplasia of the lymph vessels and/or nodes. Lymphoscintigraphy allows early diagnosis. OBJECTIVES: To assess the frequency of contralateral LE by lymphoscintigraphy in children with unilateral primary LE of one limb; to assess facets of clinical bilateralization of LE. METHODS: This retrospective single-centre study included children with unilateral LE followed up at the Tours university hospital centre between 2004 and 2014. Parents were contacted by phone to obtain follow-up data. RESULTS: Of the 13 children included, 6 (46%) displayed bilateral lymphatic anomalies on lymphoscintigraphy. Within a median follow-up period of 6 years, clinical bilateralization was observed in one girl after progression of her LE for 7 years; in her case, bilateral lymphatic insufficiency was detected at the initial lymphoscintigraphy. CONCLUSION: While contralateral subclinical lymphatic insufficiency is frequent in children with unilateral primary LE of the limbs, clinical bilateralization appears only rarely.
Assuntos
Linfedema/diagnóstico por imagem , Linfocintigrafia/métodos , Adolescente , Criança , Pré-Escolar , Diagnóstico Tardio , Progressão da Doença , Feminino , Seguimentos , Humanos , Lactente , Extremidade Inferior/diagnóstico por imagem , Linfangiectasia/diagnóstico por imagem , Vasos Linfáticos/anormalidades , Vasos Linfáticos/diagnóstico por imagem , Masculino , Estudos Retrospectivos , Extremidade Superior/diagnóstico por imagemAssuntos
Linfedema/fisiopatologia , Criança , Análise Mutacional de DNA , Diagnóstico Diferencial , Fatores de Transcrição Forkhead/genética , Humanos , Linfangiogênese/genética , Linfangiogênese/fisiologia , Linfedema/diagnóstico , Linfedema/genética , Neovascularização Fisiológica/genética , Neovascularização Fisiológica/fisiologia , Fatores de Transcrição SOXF/genética , Receptor 3 de Fatores de Crescimento do Endotélio Vascular/genéticaRESUMO
A fortuitously discovered case of feline leishmaniosis is reported. The parasites were found in the skin and the bone marrow of a domestic female cat that spontaneously died after a few weeks of evolution. Serological tests for FeLV, FIV and PIF virus detection gave negative results. By using Western blot serology, a characteristic pattern of leishmaniosis was obtained and by performing an isoenzyme electrophoresis, a Leishmania infantum MON-1 strain was identified. The same zymodeme is implicated in most of the canine and human leishmaniosis in Southern Europe. A study on the prevalence of asymptomatic feline leismaniosis is foreseen.
