RESUMO
Measurements of urinary proteins, blood and urinary cadmium, and in vivo kidney and liver cadmium have been made for a group of workers at several times between 1981 and 1990. The possibility of the introduction of measurement artifacts due to the use of different in vivo measurement systems has been assessed and is considered to be small. Changes in cadmium body burden with time have been studied in relation to kidney function. The results suggest several interesting patterns, although more data are needed to elucidate these further. They do, however, show the effectiveness of good hygiene in the workplace.
Assuntos
Cádmio/efeitos adversos , Metalurgia , Exposição Ocupacional , Carga Corporal (Radioterapia) , Cádmio/sangue , Cádmio/urina , Humanos , Rim/química , Fígado/química , Estudos Longitudinais , Masculino , Proteínas de Ligação ao Retinol/urina , Microglobulina beta-2/urinaRESUMO
Biochemical indicators of renal dysfunction have been compared with liver and kidney cadmium levels measured by neutron activation analysis in a group of 37 cadmium smelters. Higher than normal concentrations of cadmium in the liver reflect past exposure; they were associated with evidence of renal dysfunction in workers exposed to cadmium for more than 10 years. A small group of 6 workers exposed to cadmium for only a short time (mean = 4.6 years) had high hepatic cadmium concentrations but normal renal function. Longitudinal studies are required to establish the natural history of renal dysfunction following cadmium accumulation in industrial workers.
