RESUMO
The state of pro-oxidant-antioxidant homeostasis in guinea pigs exposed to whole-body fractionated X irradiation (5 fractions of 0.2 Gy at a 24 hr interval, up to total dose of 1.0 Gy, at a dose rate of 0.425 R/min) and a possibility of its disturbance correction with the complex of vitamins C, E and P was studied. Accumulation of primary and secondary lipid peroxidation products, decrease of the ascorbic acid content, increase of the content of its oxidized forms (dehydroascorbic acid and diketogulonic acid) in radiosensitive (spleen and small intestine) and radioresistant organs were found. Antioxidant complex administration reduced the disturbances of pro-oxidant-antioxidant homeostasis, but did not provide complete normalization.
Assuntos
Antioxidantes/efeitos da radiação , Antioxidantes/uso terapêutico , Ácido Ascórbico/uso terapêutico , Catequina/uso terapêutico , Homeostase/efeitos da radiação , Lesões Experimentais por Radiação/tratamento farmacológico , Lesões Experimentais por Radiação/metabolismo , Espécies Reativas de Oxigênio/efeitos da radiação , Vitamina E/análogos & derivados , alfa-Tocoferol/análogos & derivados , Animais , Antioxidantes/metabolismo , Ácido Ascórbico/metabolismo , Ácido Ascórbico/efeitos da radiação , Relação Dose-Resposta à Radiação , Combinação de Medicamentos , Cobaias , Peroxidação de Lipídeos/efeitos da radiação , Masculino , Espécies Reativas de Oxigênio/metabolismo , Chá , Fatores de Tempo , Tocoferóis , Vitamina E/uso terapêutico , Irradiação Corporal TotalRESUMO
The data on the specific features of the polyclonal action of gram-negative bacteria on primary immune response to sheep red blood cells in oppositely reacting mouse strains are presented. Staphylococcus aureus and Bacterium flavum peptidoglycans have been found to increase the amount of antibody producing cells to thymus-dependent antigen only in the spleen of low-responsive mice. At the same time differences in the amino acid composition of these heteropolymers do not affect their stimulating activity. Differences between the capacity of B. flavum peptidoglycans to induce the activation of B cells in mice of different strains have been established.
