RESUMO
The effects of terbutaline, ephedrine, and placebo on the cardiovascular and pulmonary systems have been compared in 24 asthmatic children. Ephedrine and terbutaline were both found to be effective bronchodilators, with onset of action within 30 minutes. The bronchodilator effect of ephedrine was maintained for three hours, while terbutaline was active for five hours. Terbutaline caused significantly greater improvement in pulmonary functions than did ephedrine. Both terbutaline and ephedrine were associated with clinically insignificant changes in blood pressure and pulse rate. The only significant side effect observed was hand tremor in children receiving terbutaline and this appeared only early in the course of drug treatment. There was no evidence of tolerance to the bronchodilator effect of ephedrine or terbutaline after eight weeks of therapy.
Assuntos
Asma/tratamento farmacológico , Efedrina/uso terapêutico , Terbutalina/uso terapêutico , Adolescente , Pressão Sanguínea/efeitos dos fármacos , Criança , Ensaios Clínicos como Assunto , Método Duplo-Cego , Avaliação de Medicamentos , Efedrina/efeitos adversos , Efedrina/farmacologia , Humanos , Placebos , Pulso Arterial/efeitos dos fármacos , Testes de Função Respiratória , Terbutalina/efeitos adversos , Terbutalina/farmacologiaRESUMO
Alternate-day corticosteroid therapy had been shown to have a suppressive effect on delayed hypersensitivity skin responses elicited on repeated skin testing in an asthmatic population. While the clinical meaning is not clear, it indicates that alternate-day corticosteroid therapy may have a subtle effect on cellular hypersensitivity responses.
Assuntos
Asma/tratamento farmacológico , Hipersensibilidade Tardia , Prednisolona/farmacologia , Prednisona/farmacologia , Adolescente , Antígenos , Candida albicans/imunologia , Criança , Pré-Escolar , Esquema de Medicação , Feminino , Humanos , Masculino , Prednisolona/uso terapêutico , Prednisona/uso terapêutico , Testes CutâneosRESUMO
The diurnal variation in total eosinophil count (TEC) in asthmatic children not on medications or on thophylline-containing bronchodilators orally every 6 hr is similar to that reported in normal subjects, with a decrease in TEC in the morning and an increase in the evening. Asthmatic children taking prednisone in 8:00 A.M. on alternate days have diurnal variations in TEC on the "day off" prednisone similar to those on normal children. On the "day on" prednisone, administered either on a daily or alternate-day basis, TECs approach zero 4 to 8 hr after prednisone is taken. The TEC then increases in the evening as it does in children not taking prednisone.
Assuntos
Asma/sangue , Eosinófilos , Adolescente , Aminofilina/uso terapêutico , Asma/tratamento farmacológico , Criança , Ritmo Circadiano , Humanos , Contagem de Leucócitos , Prednisolona/uso terapêuticoRESUMO
In 36 asthmatic children 8:00 a.m. plasma cortisol levels were compared with changes in their total eosinophil count (TEC) from 8:00 a.m. to 9:30 a.m. All children with low cortisol levels had decreases in TEC of less than 2%, whereas 78% of children with normal cortisol levels had decreases greater than 15%. All children with decreases greater than 15% had normal cortisol levels.
