1.
Biomed Pharmacother
; 43(1): 19-23, 1989.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2730949
RESUMO
Nicotine was found to markedly potentiate haloperidol-induced hypokinesia in rats. Nicotine alone was without effect. Subsequently, concurrent administration of 2 mg nicotine gum to 10 Tourette syndrome patients being treated with haloperidol produced a substantial decrease in tics and improvement of concentration and attention span. Nicotine gum alone was without effect. While 80% of children showed improvement with nicotine gum, 70% completely discontinued the gum because of side-effects, primarily involving nausea and bitter taste. Nicotine may prove useful for treating other neuroleptic responsive disorders, such as schizophrenia and Huntington's disease.
Assuntos
Haloperidol/farmacologia , Nicotina/farmacologia , Síndrome de Tourette/tratamento farmacológico , Adolescente , Animais , Comportamento Animal/efeitos dos fármacos , Catalepsia/induzido quimicamente , Goma de Mascar , Criança , Pré-Escolar , Interações Medicamentosas , Feminino , Haloperidol/uso terapêutico , Humanos , Masculino , Nicotina/administração & dosagem , Nicotina/uso terapêutico , Ratos , Ratos Endogâmicos , Transtornos de Tique/tratamento farmacológico , Síndrome de Tourette/psicologia
2.
Perspect Psychiatr Care
; 21(3): 90-3, 1983.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6562460