RESUMO
Schisaridrae chinensis is the dried ripe fruit of Schisan- drae chinensis in the magnolia family.In recent years studies have shown that Schisandra chinensis has significant effects on the treatment of Alzheimer's disease, Parkinson's disease, depressive disorder, anxiety disorder and other neurological and mental diseases.Schisandra chinensis has shown to inhibit the activation of microglia and astrocytes, regulate the level of central neurotransmitters and protect neurons.In this paper, the effects of Schisandrae chinensis on various neurological and mental diseases and the underlying mechanisms are reviewed in order to provide reference for the clinical application of Schisandrae chinensis.
RESUMO
OBJECTIVE: To investigate the effects of interval training on calcium transient and contractile function in ischemic ventricular myocytes of rats with myocardial infarction and their synchronization. METHODS: Twenty-four male sprague-dawley rats in three years old, were randomly divided into three groups (n=8): sham-operated group(S), sedentary MI group(MI) and MI with interval training group (ME). The MI model was established by ligation of the left anterior descending coronary artery. The rats in ME group started training 1 week after MI operation. The S model was established by threading only without ligation. ME model took one week adaptive training, 10 m/min and 30 min/d, then took subsequently 8-week aerobic interval training: 10 min×10 m/min, then reran the rats with 2 intensities 15 m/min×6 min and 25 m/min×4 min, 1 h/d, 5 d/week. After training 24 hours, the cardiomyocytes of all groups were isolated by using the Langendorff fusion system. The contractile function and calcium transient of single ventricular myocyte in myocardial infarction adult rats were detected by IonOptix. Calcium transients were measured as [Ca2+]i amplitude, departure velocity, ratio, TTB50ï¼ , TTP and TTP50%, return velocity and ratio amplitude. PTA, SL, ±dl/dtmax and SL shortening% were tested to evaluate contractility. RESULTS: Compared with S, the levels of [Ca2+]i amplitude, departure velocity, ratio amplitude and return velocity, SL shortening%, PTA and ±dl/dtmax of MI were decreased(Pï¼0.01), the levels of TTP, TTP50% and TTB50% of MI were increased(Pï¼0.01); Compared with MI, the levels of departure velocity, ratio amplitude, return velocity and [Ca2+]i amplitude of ME were increased(Pï¼0.01), the levels of TTB50%, TTP and TTP50% of ME were decreased(Pï¼0.01, Pï¼0.05). The levels of SL shortening%, PTA and ±dl/dtmax of ME were increased(Pï¼0.01, Pï¼0.05). CONCLUSION: Interval training can improve calcium transient and contractile function of single ventricular myocyte in myocardial infarction adult rats.
