RESUMO
Cervical cancer incidence and mortality in Poland is among the highest in Europe. To investigate infection with different human papillomaviruses (HPV) in Warsaw, Poland, we obtained cervical cell specimens from 834 women aged 18-59 years from the general population, and 88 cervical cancers. DNA of 44 HPV types was detected using a GP5+/6+-based PCR assay. HPV prevalence was 16.6% in the general female population, being highest (24.2%) in women aged 25-34 years, notably among unmarried women (37.3%). HPV prevalence fell to 8.6% at ages 55-59. High-risk HPV prevalence was 11.3%, with HPV16 being the most common type (3.7%). All but one cervical cancer were high-risk HPV-positive, although the importance of HPV16 (73%) was much greater, and multiple infections fewer (1%), than among HPV-positive women in the general female population. In summary, we report a relatively high burden of HPV infection in Warsaw, Poland, where 79% of cervical cancers are theoretically preventable by HPV16/18 vaccines.
Assuntos
Infecções por Papillomavirus/epidemiologia , Displasia do Colo do Útero/epidemiologia , Neoplasias do Colo do Útero/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Alphapapillomavirus/isolamento & purificação , Feminino , Humanos , Estado Civil/estatística & dados numéricos , Pessoa de Meia-Idade , Invasividade Neoplásica , Polônia/epidemiologia , Prevalência , Fatores de Risco , Parceiros Sexuais , Neoplasias do Colo do Útero/virologia , Displasia do Colo do Útero/virologiaRESUMO
The prevalence of human papilloma virus (HPV) DNA in different histological subtypes of cervical adenocarcinoma and related tumors was examined using formalin-fixed, paraffin-embedded tissue samples from 105 primary cervical adenocarcinomas and adenosquamous carcinomas. Broad-spectrum HPV DNA amplification and genotyping was performed with the SPF10 primer set and line probe assay (LiPA), respectively. HPV DNA was detected in 82 of 90 (91%) mucinous adenocarcinomas, encompassing endocervical, intestinal, and endometrioid histological subtypes, and in nine of nine adenosquamous tumors (100%). HPV DNA was not detected in any nonmucinous adenocarcinomas including clear cell, serous, and mesonephric carcinomas (0/6). The most common viral types detected in adenocarcinoma were HPV 16 (50%) and HPV 18 (40%), followed by HPV 45 (10%), HPV52 (2%), and HPV 35 (1%). Multiple HPV types were detected in 9.7% of the cases. In conclusion, mucinous adenocarcinomas and adenosquamous carcinomas of the cervix demonstrate a very high prevalence of HPV DNA, similar to that reported for cervical squamous cell carcinoma. Only rare histological variants of cervical adenocarcinoma seem unrelated to HPV infection.
Assuntos
Adenocarcinoma/patologia , Adenocarcinoma/virologia , DNA Viral/análise , Papillomaviridae/genética , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/virologia , Adenocarcinoma Mucinoso/patologia , Adenocarcinoma Mucinoso/virologia , Adulto , Carcinoma Adenoescamoso/patologia , Carcinoma Adenoescamoso/virologia , Feminino , Humanos , Pessoa de Meia-Idade , PrevalênciaRESUMO
A case of a preterm infant who died with multiorgan, mainly cerebro-oculo-cutaneous malformations is presented. The brain dysgenesias consist of early disturbances of neuronal migration. They result on appearance of nodular subcortical heterotopias, cortical anomalies including pachy- and polymicrogyria and focal intrusion of numerous abnormally migrating nerve cells into leptomeninges. A various degree of nerve and glial cell maturity was observed within heterotopic tissue. The other malformations include eye, skin and internal organs anomalies. Similarities and differences between our case and another previously described cases were discussed but it seems difficult to include the analysed case into one of the known syndromes.
Assuntos
Encéfalo/anormalidades , Movimento Celular , Coristoma , Feminino , Proteína Glial Fibrilar Ácida , Humanos , Recém-NascidoRESUMO
An unusual case is described of Bartholin's gland carcinoma which developed 28 years after radiotherapy for a cervical carcinoma. The tumor showed three-directional differentiation with predominance of the papillary non-invasive transitional cell pattern.
Assuntos
Glândulas Vestibulares Maiores , Carcinoma de Células Escamosas/radioterapia , Carcinoma de Células de Transição/patologia , Neoplasias do Colo do Útero/radioterapia , Neoplasias Vulvares/patologia , Idoso , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Neoplasias Primárias Múltiplas , Neoplasias Induzidas por Radiação , Neoplasias do Colo do Útero/patologiaRESUMO
The paper is a histo-clinical analysis of 75 cases of vulvar dystrophy defined so far as leukoplakia or kraurosis vulvae. The series included 31 cases of hypertrophic dystrophy, 34 cases of lichen sclerosus and 10 cases of mixed dystrophy. In 52 cases changes developed after menopause. In two cases cellular atypia was found. Itching was the most frequent physical symptom. In the paper current views on the connection vulvar dystrophy with the development of invasive vulvar carcinoma have also been discussed.
Assuntos
Doenças da Vulva/patologia , Adulto , Idoso , Feminino , Humanos , Hipertrofia , Menopausa , Pessoa de Meia-Idade , Lesões Pré-Cancerosas , Vulva/patologia , Doenças da Vulva/complicações , Neoplasias Vulvares/etiologiaRESUMO
The paper describes two cases of Krukenberg tumors with accompanying "arrested secretion" pattern in the endometrium. Both patients presented with a vaginal bleeding--in one case a suspicion of Krukenberg tumor was made solely on the basis of evaluation of curettage. In postmenopausal patients whose endometrium presents "arrested secretion" pattern, and who deny any progestagen therapy or substitution, the possibility of an ovarian metastatic tumor should be taken into account.