[Modern ideas about pain syndrome in Parkinson's disease].

The analysis of the literature dedicated to modern ideas and achievements in the study of the pathogenesis, the incidence and characteristics of the clinical manifestations of pain syndromes in Parkinson's disease. It is shown that the disease is characterized by a variety of painful phenomena, combining features of the central and peripheral pain. Peripheral mechanisms of pain are realized as a consequence of mixed neuropathy (predominantly axonopathy) sensory and motor fibers. When electroneuromyographic study found a reduction of the amplitude sensory capacity, latency increase and decrease the speed of the pulse.

[Persistence of type 1 human immunodeficiency virus (HIV-1) in MT-4 cells in presence of alpha-interferon]. / Persistentsiia virusa immunodefitsita cheloveka tipa 1 (Vich-1) v prisutstvii alpha-interferona v kletkakh MT-4.

The development of HIV infection during serial passages of HIV-1 strains with different replication capacity was studied in the presence of natural human alpha-interferon (IFN-alpha). The virus activity was evaluated by accumulation of virus-specific proteins in cells and culture fluid, determined by Western blot method and analysis of viral DNA in the cells by polymerase chain reaction. IFN-alpha suppressed replication of HIV-1/IIIB and 1974. The replication of strain 1974 (with a 10-fold lower replicative activity than strain IIIB) was inhibited during the first passage and of strain IIIb during the second passage. After the fourth passage IFN-2 alpha completely suppressed the replication of strain 1974, and the virus activity did not manifest after 4 consecutive co-culturings of cells from fourth viral passage with intact cells without IFN-alpha. A population of viral particles whose replicative activity was virtually undetected in the presence of IFN-alpha seemed to persist during serial passages of strain IIIB in MT-4 cells. On the other hand, the virus replication was restored during the first co-culturing of cells from the virus subculture with intact cells in the absence of IFN-alpha. Presumably, an increase in the level of IFN-alpha in the blood of HIV-infected patients at late stages of AIDS is not accidental and is caused by appearance of more virulent variants of the virus.

[An assessment of the immunoepidemiological efficacy of a liquid cultured killed vaccine against tick-borne encephalitis virus strain 205 in the Maritime Territory]. / Otsenka immunoépidemiologicheskoi éffektivnosti zhidkoi kul'tural'noi ubitoi vaktsiny protiv kleshchevogo éntsefalita shtamm 205 v usloviiakh Primorskogo kraia.

Inactivated vaccine against tick-borne encephalitis (TBE), prepared on the basis of strain 205, is characterized by epidemiological (53%) and immunobiological activity. The appearance of a few TBE cases among the vaccinees is probably due to different maturation rate of immune response to various strains (different specificity of immune response). A suggestion has been made that no inactivated vaccine prepared from a single strain can produce a reliable protective effect because of pronounced heterogeneity of the population of TBE virus.