Assuntos
Altitude , Doença das Coronárias/fisiopatologia , Estâncias para Tratamento de Saúde , Hemodinâmica/fisiologia , Adulto , Angina Pectoris/fisiopatologia , Angina Pectoris/terapia , Clima , Doença das Coronárias/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Indução de Remissão , TadjiquistãoRESUMO
Clinical symptoms, atherogenic (cholesterol, triglycerides, beta-lipoproteins + pre-beta-lipoproteins, low-density lipoprotein cholesterol, very low density lipoprotein cholesterol, atherogenic coefficient) as well as antiatherogenic (alpha-lipoproteins, high density lipoprotein cholesterol and its proportion in total cholesterol) lipoproteins, and phenotypes were examined in 727 individuals (330 normal subjects and 397 atherosclerotic patients), living in two different areas of Tadzhikistan (830 and 2200 m above sea-level). In midaltitude dwellers coronary atherosclerosis was associated with low incidence of clinical and electrocardiographic coronary signs and a comparatively favorable clinical course, apparently due to low atherogenic and high antiatherogenic lipid parameters, the absence of type-4-hyperlipoproteinemia and low incidence of type-2B hyperlipoproteinemia.