RESUMO
In review provides information about the function oft the body of chaperones and their role in the development of pathological processes, including--atherosclerosis and coronary heart disease. Marked comminications systems chaperones to the immune and endocrine systems, and inflammation.
Assuntos
Chaperonina 60/metabolismo , Doença das Coronárias/imunologia , Doença das Coronárias/metabolismo , Proteínas de Choque Térmico HSP90/metabolismo , Proteínas Mitocondriais/metabolismo , Apoptose/imunologia , Apoptose/fisiologia , Doença das Coronárias/patologia , Citocinas/biossíntese , Humanos , Macrófagos/imunologia , Macrófagos/metabolismo , Miocárdio/imunologia , Miocárdio/metabolismo , Miocárdio/patologia , Miócitos Cardíacos/imunologia , Miócitos Cardíacos/metabolismo , Miócitos Cardíacos/patologia , Dobramento de ProteínaRESUMO
The effect of continuous single and combined influence of exogenous stress factors (ethanol and low intensity gamma-radiation) on cytochrome P450 2E1 (1.14.14.1) expression in mice liver was studied. The chronic ethanol intake induced Cyp2E1 protein expression but not increased Cyp2e1 mRNA level. The first week of continuous combined influence of ethanol and gamma-irradiation was characterized by the increase of Cyp2E1 protein level, that was back to normal on second week. A small decrease of this index was observed at the end of the fifth week. The changes of Cyp2E1 protein amount accompanied the decrease of Cyp2e1 mRNA level.
Assuntos
Citocromo P-450 CYP2E1/biossíntese , Etanol/toxicidade , Raios gama/efeitos adversos , Fígado/enzimologia , Adaptação Fisiológica/efeitos dos fármacos , Adaptação Fisiológica/efeitos da radiação , Animais , Citocromo P-450 CYP2E1/genética , Radicais Livres/metabolismo , Expressão Gênica/efeitos dos fármacos , Expressão Gênica/efeitos da radiação , Fígado/efeitos dos fármacos , Fígado/efeitos da radiação , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Estresse Oxidativo/efeitos dos fármacos , Estresse Oxidativo/efeitos da radiação , Fatores de TempoRESUMO
ATP activity of actomyosin in dilated cardiomyopathy (DCMP) was studied together with impact on the above activity of tropomyosin-troponin regulatory complexes recovered from the normal myocardium and cardiac muscle of a DCMP patient. Recordable in DCMP was a striking decline (1.5-fold) in ATP activity of actomyosin. But no significant difference was to be seen in sensitivity to Ca2+ ions of actomyosins obtained from the normal myocardium and cardiac muscle of the DCMP patient. The cardial tropomyosin-troponin regulatory complex from the DCMP patient's myocardium was shown to be endowed with somewhat more manifest activity compared to the analogous complex recovered from the normal myocardium.