[The anticlastogenic effect of ascorbic acid in relation to the damages induced in human lymphocytes by the photomutagenic action of 8-methoxypsoralen and by ammonium molybdate]. / Izuchenie antiklastogennogo éffekta askorbinovoi kisloty po otnosheniiu k povrezhdeniiam, indutsirovannym v limfotsitakh cheloveka fotomutagennym deistviem 8-metoksipsoralena i molibdenatom ammoniia.

In experiments with cultured human lymphocytes anticlastogenic effect of ascorbic acid (AA) with respect to photomutagenic action of 8-methoxypsoralen (8-MOP) and ammonium molibdenate (Mo) was studied. It was found that AA effectively protected from mutagenic action of Mo. Effective protection of cells from 8-MOP monoadducts and DNA interstrand links was also observed.

[Modification with ascorbic acid of the level of spontaneous and induced chromosome aberrations and sister chromatid exchanges in lymphocytes of workers in contact with molybdenum salts]. / Modifikatsiia askorbinovoi kisloty spontannogo i indutsirovannogo urovnei KhA i SKhO v limfotsitakh rabochikh kontaktiruiushchikh s soliami molibdena.

Five workers of molybdenum gilding at the metallurgical works were observed prior to and after administration of ascorbic acid. Tests for chromosomal aberrations (CA) and sister chromatid exchanges (SCE) were used as the criteria for estimation. Individual sensitivity to the chemicals was revealed in the workers. Administration of ascorbic acid caused reduction of the level of chromosomal structural rearrangements.

[Genotoxic effects of molybdenum and its derivatives in an experiment on Drosophila and mammals]. / Genotoksicheskie éffekty molibdena i ego proizvodnykh v éksperimente na drozofile i mlekopitaiushchikh.

As a result of research it is established that molybdenum shows the most pronounced genetic activity at the early stages of spermatogenesis. Genetic effects of molybdenum and its modification by vitamin S are registered in the test of dominant lethal mutations. The cytogenetic activity of molybdenum, the molybdenic candle-end and its modification by antibacterial preparation have been revealed in the cells of mammalian marrow.

[The genetic action of ammonium molybdate and cadmium chloride and iodide]. / Izuchenie geneticheskogo deistviia molibdata ammoniia, khloristogo i iodistogo kadmiia.

Ammonium molybdate cadmium iodide and cadmium chloride have been studied in test for their genotoxic effect on induction of DNA-cellular bonding, extrasynthesis of DNA in spermatozoa of mice as well as in test to estimate a fertility criterion of Drosophila males. Ammonium molybdate, cadmium iodide and cadmium chloride are stated to be able to induce injuries of native DNA in test on induction of DNA-cellular bonding and DNA-sex cells of mice and Drosophila melanogaster in dominant-lethal test and in experiments on estimation of a fertility coefficient of Drosophila males, respectively.

[The detection of high-risk groups among workers in contact with heavy metals based on an analysis of chromosome aberrations and sister chromatid exchanges]. / Vyiavlenie grupp povyshennogo riska sredi rabochikh, kontaktiruiushchikh s tiazhelymi metallami, na osnove analiza khromosomnykh aberratsii i sestrinskikh khromatidnykh obmenov.

Heavy metal salts, the workers from molybdenum, tungsten and cobalt plants to make in contact with, reveal their mutagenic activity. Individual sensitivity to heavy metal salts has been analyzed through the example of molybdenum. Chromosome aberrations and sister chromatid exchanges have been studied for the regularities of their formation in lymphocytes of workers depending on the length of service. Sensitivity of tests of chromosome aberrations and sister chromatid exchanges has been compared to reveal genetic consequences of these types of the effects.

[Decrease in repair processes in lymphocytes of workers exposed to heavy metals]. / Snizhenie reparativnykh protsessov v limfotsitakh rabochikh, kontaktiruiushchikh s tiazhelymi metallami.

Mechanisms of DNA repair in lymphocytes of persons having occupational contact with heavy metal salts for at least 10 years were investigated. The long-term exposure to heavy metal salts did not result in development of mechanisms of adaptation to the respective metals, as shown by increased DNA sensitivity to these compounds and by decrease in the repair activity. However, in some cases, resistance to other mutagens, 4-NQO, in particular, was observed.

[Genotoxic effects of heavy metals and their salts in an experiment on Drosophila and mammals]. / Genotoksicheskie éffekty tiazhelykh metallov i ikh solei v éksperimente na drozofile i mlekopitaiushchikh.

Analysis of data on the influence of different metals (cadmium, cobalt, molybdenum) on the Drosophila melanogaster cells has revealed a considerable genotoxic effect of cadmium salts which manifests in the high percentage of cells elimination at the early stages of spermatogenesis--the premeiotic cells. The modifying effect of molybdenum in the combination with cadmium and molybdenum decreasing the percentage of the progeny fall may be induced by activation of the reparation systems. In the bone marrow cells of mice Cd ions modify cytogenetic effects of the AB preparation, intensifying its mutagenic activity in some cases.