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1.
Int J Pharm ; 602: 120603, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-33862133

RESUMO

In this study, a quantitative relationship between material properties, process settings and screw feeding responses of a high-throughput feeder was established via multivariate models (PLS). Thirteen divergent powders were selected and characterized for 44 material property descriptors. During volumetric feeder trials, the maximum feed capacity (FCCmax), the relative standard deviation on the maximum feed capacity (RSDFCmax), the short term variability (STRSD) and feed capacity decay (FCdecay) were determined. The gravimetric feeder trials generated values for the mass flow rate variability (RSDLC), short term variability (STRSD) and refill responses (Vrefill and RSDrefill). The developed PLS models elucidated that the material properties and process settings were clearly correlated to the feeding behavior. The extended volumetric feeder trials pointed out that there was a significant influence of the chosen screw type and screw speed on the feeding process. Furthermore, the process could be optimized by reducing the feeding variability through the application of optimized mass flow filters, high frequency vibrations, independent agitator control and optimized top-up systems. Overall, the models could allow the prediction of the feeding performance for a wide range of materials based on the characterization of a subset of material properties greatly reducing the number of required feeding experiments.


Assuntos
Parafusos Ósseos , Tecnologia Farmacêutica , Comportamento Alimentar , Análise Multivariada , Pós
2.
J Burn Care Res ; 28(3): 442-6, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17438483

RESUMO

Approximately 50% of burn injuries involve the neck and head region. Because both appearance and function must be taken into account with burns of this area, several consecutive reconstructions will be performed. With a focus on improving outcome after burn injury, we underline the method of grafting as a very important element in primary surgery. With our special excision and grafting technique, we aim to achieve a reconstruction that deals with mobility and aesthetics. Consequently, necessary reconstructive procedures may be fewer and of less magnitude. We describe this surgical technique in detail. In this study we surgically treated 39 patients with sustained facial and neck burns. For 22 patients this surgical treatment circumvented the need to perform any secondary reconstructions. The proposed treatment involves a special grafting technique after pretreatment with a topical agent in combination with early pressure therapy.


Assuntos
Queimaduras/cirurgia , Traumatismos Faciais/cirurgia , Lesões do Pescoço/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Transplante de Pele , Resultado do Tratamento , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fatores de Tempo
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