RESUMO
This study examined combinations of the recombinant human cytokines, tumor necrosis factor alpha and interferon gamma, with doxorubicin and dactinomycin as well as other drugs on six squamous cell carcinoma cell lines of head and neck origin using the 3(4,5-dimethylthiazol-2-yl)2,5-diphenyl-tetrazolium bromide proliferation assay. Interferon gamma significantly enhanced the cytotoxicity of tumor necrosis factor alpha with dactinomycin on all six cell lines investigated, while in four of six cell lines the cytotoxicity of tumor necrosis factor alpha with doxorubicin was significantly augmented by interferon gamma. Additional experiments showed no effect with either cytokine in combination with cisplatin, fluorouracil, methotrexate, or etoposide. These data demonstrate that human recombinant cytokines in concert with certain drugs improve in vitro cytotoxicity and may have a potential for improving in vivo therapy.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia , Carcinoma de Células Escamosas/tratamento farmacológico , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Interferon gama/farmacologia , Fator de Necrose Tumoral alfa/farmacologia , Carcinoma de Células Escamosas/terapia , Quimioterapia Adjuvante , Dactinomicina/administração & dosagem , Dactinomicina/farmacologia , Doxorrubicina/administração & dosagem , Doxorrubicina/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Sinergismo Farmacológico , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Interferon gama/administração & dosagem , Proteínas Recombinantes/farmacologia , Células Tumorais Cultivadas/efeitos dos fármacos , Fator de Necrose Tumoral alfa/administração & dosagemRESUMO
Inverted papillomas of the oral cavity are rare lesions. Although in the seven oral cases previously reported the lesions were benign, approximately 10% to 15% of inverted papillomas of the nasal cavity and paranasal sinuses develop or are associated with squamous cell carcinoma. This report presents a case of squamous cell carcinoma arising in an inverted papilloma of the buccal mucosa. Histologically, this lesion demonstrated the morphologic features of inverted papilloma in the superficial portion, and squamous carcinoma in deeper sections. This case suggests that although rare, inverted papillomas of the oral cavity should be considered potentially malignant or capable of harboring a malignancy.
Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias Bucais/patologia , Neoplasias Primárias Múltiplas/patologia , Papiloma/patologia , Idoso , Humanos , Masculino , Mucosa Bucal/patologiaAssuntos
Aberrações Cromossômicas/genética , Cromossomos Humanos Par 16 , Genes Dominantes , Triagem de Portadores Genéticos , Doenças Renais Policísticas/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Alelos , Transtornos Cromossômicos , Mapeamento Cromossômico , Sondas de DNA , Dinamarca , Feminino , Frequência do Gene , Marcadores Genéticos , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Linhagem , FenótipoRESUMO
A patient with cyclic neutropenia was followed for 20 years. After 16 years she developed a permanent agranulocytosis, and lived for nearly four years without neutrophils in the peripheral blood. Neither prednisone, lithium nor leuco- and plasmapheresis had any effect on the neutrophil count.
Assuntos
Agranulocitose/diagnóstico , Neutropenia/diagnóstico , Adolescente , Agranulocitose/sangue , Feminino , Humanos , Contagem de Leucócitos , Pessoa de Meia-Idade , Neutropenia/sangue , PeriodicidadeRESUMO
A case of persistent cerebellar dysfunction following high-dose cytosine arabinoside (Ara-C) treatment of acute myelogenous leukemia is reported. The symptoms developed after a cumulative dose of 24 g/m2, and 6 months after the start of symptoms, the signs of cerebellar damage were unchanged. The symptoms aggravated during a subsequent low-dose therapy with Ara-C, 15 mg twice daily. This supports the presumption that this adverse effect is caused by the cumulative dose rather than by high plasma concentrations.
Assuntos
Doenças Cerebelares/induzido quimicamente , Citarabina/efeitos adversos , Adulto , Doenças Cerebelares/patologia , Citarabina/administração & dosagem , Feminino , Humanos , Leucemia Mieloide Aguda/tratamento farmacológico , Células de Purkinje/patologiaRESUMO
The annual incidence of giant cell arteritis (the term used in this study to encompass the syndromes of temporal arteritis and polymyalgia rheumatica, occurring either together or alone) was prospectively determined in a Danish county that had a population of approximately 200,000. In a single year, 46 new cases of giant cell arteritis were diagnosed, a number which corresponds to an incidence in the overall population of 21.5/10(5), and to an incidence of 76.6/10(5) for individuals age 50 years or older. These rates are higher than those previously reported in retrospective studies. The 3-year followup of all patients showed no onset of other diseases that would require a revision of the original diagnosis. There was no deviation from the age- and sex specific malignancy rate or the mortality rate in the overall population. Women had an incidence rate 4 to 5 times higher than that seen in men. Symptoms, for the most part, were the same as those found in other studies; however, vision loss was not observed during the followup period. Point prevalence at the start of the study was 37.8/10(5), which is below the rates previously reported. This is probably because of failure on the part of participating physicians to record all cases.
Assuntos
Arterite de Células Gigantes/epidemiologia , Polimialgia Reumática/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Dinamarca , Feminino , Arterite de Células Gigantes/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Polimialgia Reumática/fisiopatologia , Estudos Prospectivos , SíndromeRESUMO
Mean times of emergence of the permanent teeth (except the first and third molars and mandibular central incisors) were studied cross-sectionally in an unmixed East Greenland population in 1957 and in present West Greenland Eskimo children. In spite of differences in racial and environmental conditions, practically no difference was found between the two samples in the timing of dental development in general, taking into account the average difference in emergence times of the individual teeth. Both samples showed advanced dental development in comparison with two unmixed Caucasoid and two unmixed Mongoloid populations. The mutual similarity in timing of tooth emergence between the East and West Greenland Eskimo children considerably greater than the similarity between each of the Eskimo samples and any of the other four populations.