[The functional characteristics of the interaction of lymphokine-producing lymphocytes with granulocytes of the peripheral blood and skin in dermatosis patients]. / Funktsional'nye osobennosti vzaimodeistviia limfokinprodutsiruiushchikh limfotsitov s granulotsitami perifericheskoi krovi i kozhi bol'nykh dermatozami.

PHA-induced mononuclear production of lymphokines altering leukocyte migration was studied in patients with psoriasis, mycosis, and scabies. The findings evidence that T-cells synthesize leukocyte migration inhibition factor (LMIF) in mycosis and scabies, whereas in psoriasis they produce both LMIF and leukocyte migration stimulation factor (LMSF). Blood leukocytes of mycosis and scabies patients were more sensitive to LMIF than the cells of psoriasis patients. The 'skin fenestra' cells (granulocytes) of these patients were functionally active only in respect of LMIF, even when mononuclears synthesized LMSF, this evidencing the participation of skin leukocytes of psoriasis patients in blockage of the functional activity of LMSF-producing immunocompetent cells.

[The functional properties of interleukins in psoriasis]. / Funktsional'nye svoistva interleikinov pri psoriaze.

IL-1 and IL-2 interleukins have been studied in patients with diffuse psoriasis en papules et plaques in the stationary stage. The results evidence increased production of IL-1 and its reduced reception by the immunocompetent cells. The lymphocytes have been characterized by a reduced IL-2 synthesis and its lower binding with IL-2-sensitive cells.