RESUMO
BACKGROUND: The shrinkage of the alveolar ridge might be minimized by the ridge preservation stages and applied alloplasts, after tooth extraction. According to studies on statins, angiogenesis and osteogenesis are observed as a topical application of these drugs. OBJECTIVES: The aim of this study is to the application of simvastatin in terms of bone regeneration of the alveolar ridge after tooth extraction. MATERIALS AND METHODS: This study assessed this issue through the split-mouth method which assessed 10 dental sockets filled with simvastatin and collagen and 10 others filled just by collagen postextraction. The histological process of bone samples was observed under light microscope after 2 months at the time of fixture insertion to evaluate live and dead bone, trabecular, amorphous, and nonosteoblastic. The statistical analysis was assessed using Mann-Whitney U-test and level of significance was considered <0.05. RESULTS: Normal bone was detected in both groups. In simvastatin group, the percentages of vital bone, amorphous, and trabecular bone were more than the other group and the percentages of dead bone and nonosteoblastic were lower, although there was no significant difference in the results. CONCLUSION: Based on study results, simvastatin possibly can improve the quality of osteogenesis in the jaw bone; however, further studies are necessary to definitively result.
RESUMO
INTRODUCTION: Deep and long-lasting anesthesia is essential throughout endodontic treatment. This study was conducted to compare the effect of adding fentanyl to epinephrine-containing lidocaine on depth and duration of local anesthesia in painful maxillary molars with irreversible pulpitis (IRP). METHODS AND MATERIALS: This randomized double-blind, clinical trial with parallel design was conducted on 61 healthy volunteers; the control group received a mixture of normal saline and 2% lidocaine with 1:80000 epinephrine and the experimental group received a mixture of fentanyl and 2% lidocaine with 1:80000 epinephrine. The depth and duration of pulpal anesthesia were evaluated by means of electric pulp testing in 5-min intervals during a period of 60 min. Pain intensity was recorded five times: before injection, after injection, during access cavity preparation, initial file placement and pulpectomy using visual analog scale (VAS). All data were analyzed and compared using the chi-square and Mann-Whitney tests. RESULTS: Except for one patient in the control group, all others had deep and long-lasting anesthesia. The difference between pain intensity of the control and experimental groups was not statistically significant (P>0.05). CONCLUSION: Addition of fentanyl to conventional local anesthetic solution did not increase the effectiveness of infiltration in patients diagnosed with IRP.
